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An ESXi host reboot is not required for the following tasks:

NSX 6.3.x to NSX 6.3.x upgrades on ESXi 6.0 or later.
NSX 6.3.x VIB install after upgrading ESXi from 6.0 to 6.5.0a or later. The ESXi upgrade itself still requires a host reboot.
NSX 6.3.x VIB uninstall on ESXi 6.0 or later.

An ESXi host reboot is required for the following tasks:

NSX 6.2.x or earlier to NSX 6.3.x upgrades on any ESXi version
NSX 6.3.0 to NSX 6.3.x upgrades on ESXi 5.5
NSX 6.3.x VIB install after upgrading ESXi from 5.5 to 6.0 or later
NSX 6.3.x VIB uninstall on ESXi 5.5

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