|ISA-88 Design and Implementation Case Study for a Complex Bulk Pharmaceutical Batch Process|
|Presented at the WBF North American Conference, April 13–16, 2003, by|
|Scott C. ClarkSr. Engineerscott_clark@merck.comMerck & Co., Inc., 2778 South East SideHighway, Elkton, VA 22827, USA|
This chapter presents an ISA-88.01 implementation case study derived from a complex, multistep bulk pharmaceutical process. It methodically steps through the design process used to build the application software components that would ultimately control a campaign style of processing, consisting of five distinct trains and a representative cross-section of unit operations seen in Active Pharmaceutical Ingredient (API) bulk processing. Software ...