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The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care

Book Description

What if your cell phone could detect cancer cells circulating in your blood or warn you of an imminent heart attack? Mobile wireless digital devices, including smartphones and tablets with seemingly limitless functionality, have brought about radical changes in our lives, providing hyper-connectivity to social networks and cloud computing. But the digital world has hardly pierced the medical cocoon. Until now. Beyond reading email and surfing the Web, we will soon be checking our vital signs on our phone. We can already continuously monitor our heart rhythm, blood glucose levels, and brain waves while we sleep. Miniature ultrasound imaging devices are replacing the icon of medicine—the stethoscope. DNA sequencing, Facebook, and the Watson supercomputer have already saved lives. For the first time we can capture all the relevant data from each individual to enable precision therapy, prevent major side effects of medications, and ultimately to prevent many diseases from ever occurring. And yet many of these digital medical innovations lie unused because of the medical community’s profound resistance to change. In The Creative Destruction of Medicine, Eric Topol—one of the nation’s top physicians and a leading voice on the digital revolution in medicine—argues that radical innovation and a true democratization of medical care are within reach, but only if we consumers demand it. We can force medicine to undergo its biggest shakeup in history. This book shows us the stakes—and how to win them.

Table of Contents

  1. Praise
  2. Title Page
  3. Dedication
  4. Introduction
  5. Epigraph
  6. PART ONE • SETTING THE FOUNDATION
    1. 1 - THE DIGITAL LANDSCAPE
      1. THE WAYS WE HAVE CHANGED: THE C’S
      2. DISRUPTION AND DESTRUCTION
      3. DEALING WITH A DATA DELUGE
      4. THE DATA-DRIVEN CULTURE
      5. THE BIG PICTURE SUPER-CONVERGENCE
    2. 2 - THE ORIENTATION OF MEDICINE TODAY
    3. 3 - TO WHAT EXTENT ARE CONSUMERS EMPOWERED?
  7. PART TWO • CAPTURING THE DATA
    1. 4 - PHYSIOLOGY
      1. BLOOD GLUCOSE AND DIABETES
      2. THE ELECTROCARDIOGRAM AND HEART RHYTHM MONITORING
      3. VITAL SIGNS
      4. ASTHMA ATTACKS
      5. SLEEP APNEA
      6. MOOD DISORDERS
      7. AGING IN PLACE
      8. MEDICATION COMPLIANCE
      9. THE EMERGING WORLD AND THE MOBILE PHONE LABORATORY
      10. CONFRONTING THE CHALLENGES OF WIRELESS MEDICINE
      11. THE OFFICE VISIT OF THE FUTURE
      12. WIRELESS SENSORS IN CARS
    2. 5 - BIOLOGY
      1. GENOMICS 101
      2. A PEEK INTO THE GENOME (GWAS)
      3. TEN YEARS LATER: THE ANNIVERSARY OF THE FIRST HUMAN GENOME SEQUENCE
      4. PHARMACOGENOMICS
      5. PIVOTING TO SEQUENCING
      6. EXOME SEQUENCING
      7. WHOLE-GENOME SEQUENCING
      8. SEQUENCING TO SAVE A LIFE
      9. THE RACE TO AMP UP SEQUENCING
      10. PROGRESS IN CANCER GENOMICS
      11. BEYOND SEQUENCE: RNA, PROTEIN, METABOLITES, EPIGENOMICS
      12. PERSONAL “CONSUMER” GENOMICS
    3. 6 - ANATOMY
      1. IONIZING RADIATION
      2. HEART IMAGING
      3. BRAIN IMAGING
      4. MAPPING THE BRAIN AND CONTROLLING THE MIND
      5. CANCER IMAGING
      6. PRINTING ORGANS
    4. 7 - ELECTRONIC HEALTH RECORDS AND HEALTH INFORMATION TECHNOLOGY
      1. UNBUILDING A TOWER OF BABEL
      2. MODEL EHR HEALTH SYSTEMS
      3. CHALLENGES WITH EHRS
      4. PRIVACY AND SECURITY OF THE DATA
      5. OPEN NOTES TO PATIENTS
      6. ESCAPING THE SILO WITH PERSONAL HEALTH RECORDS
      7. THE EHRS AND PHRS OF THE FUTURE
    5. 8 - THE CONVERGENCE OF HUMAN DATA CAPTURE
      1. COMBINING WIRELESS SENSORS AND GENOMICS
      2. WIRELESS GENOMICS
      3. GENOMICS AND DRUG DEVELOPMENT
  8. PART THREE • THE IMPACT OF HOMO DIGITUS
    1. 9 - DOCTORS WITH PLASTICITY?
      1. EDUCATION
      2. ACCOUNTABILITY
      3. PHYSICIAN DEMOGRAPHICS
      4. DOCTORS AND EMAIL
      5. DOCTORS AND SOCIAL NETWORKING
      6. TELEMEDICINE
      7. NEW MODELS
      8. DIGITAL DOCTORS OF THE FUTURE?
    2. 10 - REBOOTING THE LIFE SCIENCE INDUSTRY
      1. NEW TOOLS DRIVE A NEW MODEL
      2. WIKIMEDICINE
      3. THE GUARANTEED-TO-SUCCEED MODEL
      4. DIGITAL MARKETING, TRACKING, AND SALES
      5. THE NEW MODEL TAKES HOLD
    3. 11 - HOMO DIGITUS AND THE INDIVIDUAL
      1. THE SCIENCE OF INDIVIDUALITY
      2. THE N OF 1 TO THE N OF BILLIONS
      3. THE DELIVERABLES
      4. THE NEED FOR ACTIVISM
      5. DIGITAL DYSTOPIA
      6. HOMO DIGITUS AND MEDICINE SHUMPETERED
  9. AFTERWORD
  10. Acknowledgments
  11. NOTES
  12. INDEX
  13. Copyright Page