Darwine
It was only a matter of time before a group of programmers ported Wine to Mac OS X, using the X11 system to provide the user interface. This project was called Darwine (http://darwine.sourceforge.net/), after Darwin (the Unix core of Mac OS X). The switch to Intel only helped matters, since it meant that applications designed to run on Intel chips could potentially run at (nearly) full speed via Darwine under Mac OS X.
Unfortunately, progress on Darwine has been slow, and unless you're a programmer you're likely to encounter considerable difficulty with making any arbitrary Windows application run on your Mac with the current version of Darwine.
Note
In lieu of Darwine, you may want to try a program called WineBottler, which (much like CrossOver, ...
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