Strategies for Formulations Development

6Experiments with Single and Multiple Component Constraints

";When life gives you lemons, make lemonade.";

Elbert Hubbard (1915)

Overview

Part 2 of this text covered basic design and analysis of experiments with formulations. Components could vary from 0 to 100% of the blend. In Part 3, which begins with this chapter, we discuss how to address the common situation where there are constraints on the levels of the components. At first one might be concerned about the added complexity created by the constraints, but component constraints are a reality. As the opening quotation suggests, we must find a way to deal with the constraints, and we do that in the chapter. We will discuss how upper and lower bounds on the components affect the region of ...