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Progenitor and Stem Cell Technologies and Therapies

Book Description

Progenitor and stem cells have the ability to renew themselves and change into a variety of specialised types, making them ideal materials for therapy and regenerative medicine. Progenitor and stem cell technologies and therapies reviews the range of progenitor and stem cells available and their therapeutic application.

Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies. The final part of the book considers the therapeutic use of stem and progenitor cells. Chapters review the use of adipose tissue-derived stem cells, umbilical cord blood (UCB) stem cells, bone marrow, auditory and oral cavity stem cells. Other chapters cover the use of stem cells in therapies in various clinical areas, including lung, cartilage, urologic, nerve and cardiac repair.

With its distinguished editor and international team of contributors, Progenitor and stem cell technologies and therapies is a standard reference for both those researching in cell and tissue biology and engineering as well as medical practitioners investigating the therapeutic use of this important technology.

  • Reviews the range of progenitor and stem cells available and outlines their therapeutic application
  • Examines the basic principles for the culture of stem cells before discussing technologies for particular cell types, including human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells
  • Includes a discussion of wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies

Table of Contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Dedication
  6. Contributor contact details
  7. Introduction
  8. Part I: Basic principles of stem cells
    1. Chapter 1: Basic principles for stem cell culture
      1. Abstract:
      2. 1.1 Introduction
      3. 1.2 Understanding and standardization of in vitro culture systems
      4. 1.3 Quality assurance
      5. 1.4 Documentation
      6. 1.5 Safety
      7. 1.6 Legal, ethical and regulatory compliance
      8. 1.7 Education and training
      9. 1.8 Conclusion
      10. 1.9 Acknowledgement
    2. Chapter 2: Basic principles of human embryonic stem cells
      1. Abstract:
      2. 2.1 Introduction: biological properties of human embryonic stem cells (hESC)
      3. 2.2 Historical overview
      4. 2.3 Human embryonic stem cells (hESC) in therapy – current status and strategies for the future
      5. 2.4 Human embryonic stem cells (hESC) in drug discovery – current status and strategies for the future
      6. 2.5 Specific mutation-carrying (SMC) human embryonic stem cells (hESC)
      7. 2.6 Human embryonic stem cells (hESC) utilization, the next step
      8. 2.7 Conclusion
    3. Chapter 3: Basic principles in generating induced pluripotent stem cells
      1. Abstract:
      2. 3.1 Introduction
      3. 3.2 Evolution of reprogramming and the birth of induced pluripotency
      4. 3.3 Current methods for induced reprogramming
      5. 3.4 Conclusions and future prospects
    4. Chapter 4: Basic principles of amniotic fluid and placenta stem cells
      1. Abstract:
      2. 4.1 Introduction
      3. 4.2 Amniotic fluid and placenta in developmental biology
      4. 4.3 Isolation and characterization of progenitor cells
      5. 4.4 Differentiation of amniotic fluid- and placenta-derived progenitor cells
      6. 4.5 In vivo behavior of amniotic fluid stem cells
      7. 4.6 Amniotic fluid and placenta for cell therapy
      8. 4.7 Conclusion
      9. 4.8 Acknowledgment
    5. Chapter 5: Basic principles of cord blood stem cells
      1. Abstract:
      2. 5.1 Introduction: history of cord blood stem cell technology
      3. 5.2 Cord blood collection, processing and storage
      4. 5.3 Public and private cord blood banking
      5. 5.4 Cord blood haemopoietic stem cell transplantation
      6. 5.5 Cord blood mesenchymal stem cells
      7. 5.6 Current research and future developments
      8. 5.7 Cord blood transfusion
      9. 5.8 Conclusion
    6. Chapter 6: Basic principles of multipotent stem cells
      1. Abstract:
      2. 6.1 Introduction
      3. 6.2 Hematopoietic stem cells (HSC)
      4. 6.3 Mesenchymal stem cells (MSC)
      5. 6.4 Adult stem cells with broader potential
      6. 6.5 In vitro and in vivo differentiation potential of multipotent adult progenitor cells (MAPC)
      7. 6.6 Immunomodulatory properties of multipotent adult progenitor cells (MAPC)
      8. 6.7 Conclusion
  9. Part II: Enabling cell therapy
    1. Chapter 7: Intellectual property claims to stem cell technologies: research, clinical testing and product sales
      1. Abstract:
      2. 7.1 Introduction
      3. 7.2 International overview of patent laws and stem cell policies
      4. 7.3 Introduction to the international stem cell patent landscape
      5. 7.4 Human embryonic stem cell patents
      6. 7.5 Advances in induced pluripotent stem cell patents (iPS cells)
      7. 7.6 Models for access to, and management of, stem cell patents
      8. 7.7 Conclusion
      9. 7.8 Acknowledgments
    2. Chapter 8: Regulatory considerations of stem and progenitor cell-based products: US Food and Drug Administration
      1. Abstract:
      2. 8.1 Introduction
      3. 8.2 Preparing the cellular component: chemistry, manufacturing and control considerations
      4. 8.3 Preclinical testing: pharmacology/toxicology considerations
      5. 8.4 Clinical trial considerations
      6. 8.5 Combination products: considerations when combining stem/progenitor cells with other components
      7. 8.6 Conclusion and future regulatory tools development
      8. 8.7 Acknowledgments
    3. Chapter 9: Cell therapy commercialisation
      1. Abstract:
      2. 9.1 Introduction: cells as therapies
      3. 9.2 The field to date
      4. 9.3 Commercialisation
      5. 9.4 Manufacturing
      6. 9.5 Future trends
      7. 9.6 Conclusion
      8. 9.7 Acknowledgements
      9. 9.8 Sources of further information
    4. Chapter 10: Stem cell tourism
      1. Abstract:
      2. 10.1 Introduction
      3. 10.2 Scope of the phenomenon
      4. 10.3 Problems relating to stem cell tourism
      5. 10.4 Responses
      6. 10.5 Conclusion
      7. 10.6 Acknowledgments
  10. Part III: Tissue-specific progenitor cells
    1. Chapter 11: Adipose tissue-derived stem cell biology and therapy
      1. Abstract:
      2. 11.1 Introduction
      3. 11.2 Characterization of adipose tissue-derived stromal cells
      4. 11.3 Advantages of adipose tissue-derived stem cells over other cell sources
      5. 11.4 Adipose tissue-derived stromal cells for cardiovascular repair: a joint clinical and experimental approach
      6. 11.5 Conclusion: perspectives and open questions
      7. 11.6 Acknowledgements
    2. Chapter 12: Umbilical cord blood (UCB) progenitor and stem cell biology and therapy
      1. Abstract:
      2. 12.1 Introduction
      3. 12.2 Biological characterization of umbilical cord blood (UCB) stem/progenitor cells
      4. 12.3 Therapeutic potential of umbilical cord blood (UCB) stem/progenitor cells for tissue repair or regeneration
      5. 12.4 Conclusion and future perspectives
    3. Chapter 13: Auditory progenitor stem cell biology and therapy
      1. Abstract:
      2. 13.1 Introduction
      3. 13.2 Sources of auditory progenitors
      4. 13.3 Transdifferentiation or developmental progression?
      5. 13.4 Which is the best cell type and stage for transplantation?
      6. 13.5 Future trends
    4. Chapter 14: Olfactory mucosa: neural stem and progenitor cells for nervous system repair and cell models of brain disease
      1. Abstract:
      2. 14.1 Introduction
      3. 14.2 Olfactory mucosa as source of tissue-resident stem cells
      4. 14.3 Cells with clinical application
      5. 14.4 Preclinical and clinical studies
      6. 14.5 Olfactory stem cell models of human disease
      7. 14.6 Conclusion
      8. 14.7 Acknowledgements
    5. Chapter 15: Oral cavity progenitor and stem cell biology and therapy
      1. Abstract:
      2. 15.1 Introduction
      3. 15.2 Embryonic development of teeth and supporting tissues
      4. 15.3 Tooth bud-derived stem cell types and differentiation potential
      5. 15.4 Stem cells present in postnatal teeth
      6. 15.5 Unsolved problems in the use of dental stem cells
      7. 15.6 Conclusion
    6. Chapter 16: Bone marrow mesenchymal progenitor and stem cell biology and therapy
      1. Abstract:
      2. 16.1 Introduction
      3. 16.2 Mesenchymal stem cell (MSC) biology
      4. 16.3 Mesenchymal stem cell (MSC) therapy
      5. 16.4 Conclusion
    7. Chapter 17: Progenitor and stem cell therapies for cartilage repair
      1. Abstract:
      2. 17.1 Introduction
      3. 17.2 Cell-based therapies for cartilage repair
      4. 17.3 Tissue engineering strategies for cartilage repair
      5. 17.4 Hurdles for cartilage tissue regeneration
      6. 17.5 Conclusion and future trends
      7. 17.6 Acknowledgement
    8. Chapter 18: Cardiac stem and progenitor cell biology and therapy
      1. Abstract:
      2. 18.1 Introduction: current concept of cardiac tissue homeostasis
      3. 18.2 From none to plenty: cardiac stem/progenitor cell populations within adult myocardium
      4. 18.3 Origin of cardiac stem cells in the adult human heart
      5. 18.4 Cardiac stem cell niche
      6. 18.5 Regeneration boosting
      7. 18.6 Conclusions
    9. Chapter 19: Renal progenitor and stem cell biology and therapy
      1. Abstract:
      2. 19.1 Introduction
      3. 19.2 Endogenous renal progenitor cells and regeneration
      4. 19.3 Summary and conclusions
    10. Chapter 20: Lung progenitor and stem cell biology and therapy
      1. Abstract:
      2. 20.1 Introduction: definitions of a diverse population
      3. 20.2 Lung development and stem cell zones
      4. 20.3 Resident lung stem cells and their niches
      5. 20.4 Circulating bone marrow-derived stem cells which home to the lung
      6. 20.5 Techniques for identification of lung stem cells
      7. 20.6 Disorders of lung stem cells and clinical applications in lung diseases
      8. 20.7 Induced pluripotent stem cells (iPSCs)
      9. 20.8 Conclusion: future directions for lung stem cells through bioengineered lung tissue
      10. 20.9 Acknowledgments
    11. Chapter 21: Genitourinary progenitor and stem cell biology and therapy
      1. Abstract:
      2. 21.1 Introduction
      3. 21.2 The basics of tissue engineering
      4. 21.3 Cells for use in urological tissue engineering
      5. 21.4 Biomaterials for urological tissue engineering
      6. 21.5 Tissue engineering of specific urologic structures
      7. 21.6 Conclusion
      8. 21.7 Acknowledgments
  11. Index