11.6. Summary
This chapter reviews most important issues arising in the analysis of dose-ranging trials. The following topics are discussed in the chapter.
Assessment of the dose-related trend. Dose-response analysis begins with an overall assessment of dose-related trends in the response variable. The chapter reviews contrast-based, isotonic (Bartholomew and Williams tests) and non-parametric (Jonckheere test) approaches to testing dose-response trends.
Estimation of the shape of the dose-response function. The next step after the assessment of the overall drug effect is the characterization of the underlying dose-response relationship. This is achieved by modeling dose-response functions and estimation of their parameters The chapter introduces ...
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