7.5. Models with a Bounded Response (Beta Models

The beta regression model provides another example where the information matrix can be calculated in a closed form.

7.5.1. General Model

In clinical trials, investigators often need to deal with ordinal variables containing many categories. The Beta regression model has been shown to be a good choice to analyze this type of response; see Wu, Fedorov and Propert (2005).

Figure 7-6. Left panel: Initial (open circles) and optimal (closed circles) designs. Right panel: Sensitivity functions for the initial (dashed curve) and optimal (solid curve) designs.

In this section we consider an example from ...

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