Chapter 5
Analysis of Local Anaesthetic Drugs
Local anaesthetics are the drugs used for the anaesthetic effect on the local area. The commonly employed drugs are as follows:
- Benzocaine
- Procaine
- Cocaine
- Orthocaine
The following are analytical methods used for the determination of the drugs. They are as follows:
- Spectrometric methods
- Visible method
- UV method
- Fluorimetry
- Titrimetric methods
- Residual titration
- Bromimetry
- Precipitate titration
- Titration with acid dyes
- Gravimetry
- IP methods
- Spectrometric methods:
- Visible method:
- Diazotization method: Sample is mixed with HCl and NaNO2 which act as diazotizing reagents. Then keep the solution a side for 3 min. Then add 95% alcohol and add coupling reagent such as 0.1% Bartton–Marshall reagent. ...
- Visible method:
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