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New Functional Biomaterials for Medicine and Healthcare

Book Description

Advances in processing technologies and our understanding of materials and their properties have made it possible for scientists and engineers to develop more sophisticated biomaterials with more targeted functionality. This important book provides a concise summary of the latest developments in key types of biomaterials.

The book begins with an overview of the use of biomaterials in contemporary healthcare and the process of developing novel biomaterials; the key issues and challenges associated with the design of complex implantable systems are also highlighted. The book then reviews the main materials used in functional biomaterials, particularly their properties and applications. Individual chapters focus on both natural and synthetic polymers, metallic biomaterials and bio-inert and bioactive ceramics.

New functional biomaterials for medicine and healthcare provides an ideal one-volume summary of this important field that will be essential reading for scientists, engineers and clinicians, and a useful reference text for undergraduate and postgraduate students.

  • Provides a concise summary of the latest developments in key types of biomaterials
  • The key issues and challenges associated with the design of complex implantable systems are highlighted
  • Chapters focus on both natural and synthetic polymers, metallic biomaterials and bio-inert and bioactive ceramics

Table of Contents

  1. Cover image
  2. Title page
  3. Copyright
  4. Author contact details
  5. Woodhead Publishing Series in Biomaterials
  6. Preface
  7. Chapter 1: Introduction to biomaterials and implantable device design
    1. Abstract:
    2. 1.1 Introduction
    3. 1.2 Biomaterials and their applications
    4. 1.3 Biomaterial development and realisation
    5. 1.4 Implantable systems design
    6. 1.5 Device-associated infections
    7. 1.6 Current trends in biomaterials design and fabrication
  8. Chapter 2: Natural polymer biomaterials: advanced applications
    1. Abstract:
    2. 2.1 Introduction
    3. 2.2 Chitin and chitosan
    4. 2.3 Alginate
    5. 2.4 Collagen
    6. 2.5 Gelatin
    7. 2.6 Hyaluronic acid
    8. 2.7 Fibrinogen
    9. 2.8 Silk fibroin
    10. 2.9 Viral particles and bacteriophage capsids for drug delivery
    11. 2.10 Immunocytes as ‘Trojan horses’ for molecule delivery
    12. 2.11 Future trends
  9. Chapter 3: Advanced synthetic polymer biomaterials derived from organic sources
    1. Abstract:
    2. 3.1 Introduction
    3. 3.2 Poly(ester)s and poly(ester) block copolymers
    4. 3.3 Poly(2-oxazoline)s
    5. 3.4 Poly(alkyl carbonate)s
    6. 3.5 Poly(ether)s
    7. 3.6 Polypeptides
    8. 3.7 Poly(anhydride)s
    9. 3.8 Poly(urethane)s
    10. 3.9 Conclusion
  10. Chapter 4: Advanced synthetic and hybrid polymer biomaterials derived from inorganic and mixed organic–inorganic sources
    1. Abstract:
    2. 4.1 Introduction
    3. 4.2 Synthetic inorganic polymers
    4. 4.3 Silicon-based inorganic polymers
    5. 4.4 Poly(phosphazene)s
    6. 4.5 Organic–inorganic hybrid polymers
    7. 4.6 Geopolymers
    8. 4.7 Conclusion
  11. Chapter 5: Metallic biomaterials: types and advanced applications
    1. Abstract:
    2. 5.1 Introduction
    3. 5.2 Stainless steel
    4. 5.3 Co-Cr alloys
    5. 5.4 Ti and Ti-based alloys
    6. 5.5 Noble metal alloys
    7. 5.6 Shape memory alloys
    8. 5.7 Biodegradable metals
    9. 5.8 Conclusion
  12. Chapter 6: Cytotoxicity and biocompatibility of metallic biomaterials
    1. Abstract:
    2. 6.1 Introduction
    3. 6.2 Cytotoxicity and biocompatibility of metals and alloys
    4. 6.3 Effect of load and wear on implant degradation
    5. 6.4 Macrophage-mediated inflammatory events
    6. 6.5 Role of bacterial endotoxins in triggering a particle-induced inflammatory response
    7. 6.6 Osteoclast-mediated bone resorption
    8. 6.7 Osteolysis as a function of implant-associated mechano-transduction
    9. 6.8 Surface modification as a means of enhancing biocompatibility and corrosion resistance
    10. 6.9 Conclusion
  13. Chapter 7: Bioinert ceramic biomaterials: advanced applications
    1. Abstract:
    2. 7.1 Introduction
    3. 7.2 Hardness, high compressive strength and wear resistance of bioinert refractory polycrystalline compounds
    4. 7.3 Techniques for the fabrication of bioinert ceramic implants
    5. 7.4 Conclusion
  14. Chapter 8: Advanced bioactive and biodegradable ceramic biomaterials
    1. Abstract:
    2. 8.1 Introduction
    3. 8.2 The development of bioactive ceramics for tissue engineering
    4. 8.3 Calcium phosphates
    5. 8.4 Bioactive glasses
    6. 8.5 Conclusion
  15. Index