Natural Products in Chemical Biology

CONTENTS

Preface

Contributors

PART I CHEMICAL DIVERSITY OF NATURAL PRODUCTS

1 Plant Natural Products

A. Leslie Gunatilaka

2 Marine Natural Products

Nobuhiro Fusetani

3 Microbial Natural Products

Sergio Sanchez, Silvia Guzmán-Trampe, Mariana Ávalos, Beatriz Ruiz, Romina Rodríguez-Sanoja, and Manuel Jiménez-Estrada

PART II BIOSYNTHESIS OF NATURAL PRODUCTS

4 Nonribosomal Peptides

Georg Schoenafinger and Mohamed A. Marahiel

5 Plant Terpenoids

Christopher I. Keeling and Jörg Bohlmann

6 Polyketides in Fungi

Thomas J. Simpson and Russell J. Cox

7 Modular Polyketide Synthases

Tonia J. Buchholz, Jeffrey D. Kittendorf, and David H. Sherman

8 Polyketide Polyethers

Alison M. Hill

9 Alkaloids

Sarah E. O'Connor

10 Cofactors

Ilka Haase, Markus Fischer, Adelbert Bacher, Wolfgang Eisenreich, and Felix Rohdich

11 Antibiotics

Sergey B. Zotchev

PART III NATURAL PRODUCTS IN MEDICINE

12 Pharmaceuticals: Natural Products and Natural Product Models

Sheo B. Singh

13 Natural Products as Anticancer Agents

David G. I. Kingston and David J. Newman

14 Plant-Derived Natural Products Research in Drug Discovery

Kuo-Hsiung Lee, Hideji Itokawa, Toshiyuki Akiyama, and Susan L. Morris-Natschke

Index