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Natural Products in Chemical Biology

Book Description

Based on the award winning Wiley Encyclopedia of Chemical Biology, this book provides a general overview of the unique features of the small molecules referred to as "natural products", explores how this traditionally organic chemistry-based field was transformed by insights from genetics and biochemistry, and highlights some promising future directions. The book begins by introducing natural products from different origins, moves on to presenting and discussing biosynthesis of various classes of natural products, and then looks at natural products as models and the possibilities of using them in medicine.

Table of Contents

  1. Cover Page
  2. Title Page
  3. Copyright
  4. CONTENTS
  5. PREFACE
  6. CONTRIBUTORS
  7. PART I: CHEMICAL DIVERSITY OF NATURAL PRODUCTS
    1. CHAPTER 1: PLANT NATURAL PRODUCTS
      1. 1.1 ORIGIN OF NATURAL PRODUCTS IN PLANTS
      2. 1.2 CARBOHYDRATES
      3. 1.3 PRODUCTS OF ACETATE PATHWAY
      4. 1.4 PRODUCTS OF MEVALONATE PATHWAY
      5. 1.5 PRODUCTS OF SHIKIMATE PATHWAY
      6. 1.6 ALKALOIDS
      7. 1.7 MAXIMIZATION OF CHEMICAL DIVERSITY AND PRODUCTION OF NATURAL PRODUCTS IN PLANTS
      8. REFERENCES
      9. FURTHER READING
    2. CHAPTER 2: MARINE NATURAL PRODUCTS
      1. 2.1 POLYKETIDES AND FATTY ACID DERIVATIVES
      2. 2.2 NONRIBOSOMAL PEPTIDES AND AMINO ACID DERIVATIVES
      3. 2.3 ALKALOIDS
      4. 2.4 TERPENOIDS
      5. 2.5 ACKNOWLEDGMENTS
      6. REFERENCES
      7. FURTHER READING
    3. CHAPTER 3: MICROBIAL NATURAL PRODUCTS
      1. 3.1 ANTIBACTERIALS
      2. 3.2 ANTIFUNGALS
      3. 3.3 ANTITUMOR COMPOUNDS
      4. 3.4 ANTIPARASITICS
      5. 3.5 ENZYME INHIBITORS
      6. 3.6 GASTROINTESTINAL MOTOR STIMULATORS
      7. 3.7 HERBICIDES
      8. 3.8 HYPOCHOLESTEROLEMICS
      9. 3.9 HYPOGLYCEMICS
      10. 3.10 IMMUNOSUPPRESSANTS
      11. 3.11 INSECTICIDES
      12. 3.12 CONCLUDING REMARKS
      13. 3.13 ACKNOWLEDGMENTS
      14. REFERENCES
      15. FURTHER READING
  8. PART II: BIOSYNTHESIS OF NATURAL PRODUCTS
    1. CHAPTER 4: NONRIBOSOMAL PEPTIDES
      1. 4.1 BIOLOGIC BACKGROUND
      2. 4.2 CATALYTIC DOMAINS OF NONRIBOSOMAL PEPTIDE SYNTHETASES
      3. 4.3 TECHNIQUES FOR THE PRODUCTION OF NOVEL NONRIBOSOMAL PEPTIDES
      4. REFERENCES
      5. FURTHER READING
    2. CHAPTER 5: PLANT TERPENOIDS
      1. 5.1 BIOLOGICAL BACKGROUND
      2. 5.2 CHEMISTRY
      3. 5.3 CHEMICAL TOOLS AND TECHNIQUES
      4. REFERENCES
    3. CHAPTER 6: POLYKETIDES IN FUNGI
      1. 6.1 BIOLOGICAL PROPERTIES
      2. 6.2 BIOSYNTHESIS
      3. 6.3 FUNGAL POLYKETIDE SYNTHASES
      4. 6.4 FUNGAL NR-PKS
      5. 6.5 FUNGAL PR-PKS
      6. 6.6 FUNGAL HR-PKS
      7. 6.7 CONCLUSION
      8. REFERENCES
      9. FURTHER READING
    4. CHAPTER 7: MODULAR POLYKETIDE SYNTHASES
      1. 7.1 PROTOTYPICAL POLYKETIDE BIOSYNTHESIS
      2. 7.2 POLYKETIDE DOUBLE BONDS
      3. 7.3 ATYPICAL PKS DOMAINS
      4. 7.4 ACKNOWLEDGMENTS
      5. REFERENCES
    5. CHAPTER 8: POLYKETIDE POLYETHERS
      1. 8.1 BIOLOGICAL BACKGROUND
      2. 8.2 CHEMISTRY
      3. 8.3 CHEMICAL TOOLS AND TECHNIQUES
      4. REFERENCES
      5. FURTHER READING
    6. CHAPTER 9: ALKALOIDS
      1. 9.1 BIOLOGIC BACKGROUND
      2. 9.2 ISOQUINOLINE ALKALOIDS
      3. 9.3 TERPENOID INDOLE ALKALOIDS
      4. 9.4 TROPANE ALKALOIDS
      5. 9.5 PURINE ALKALOIDS
      6. REFERENCES
      7. FURTHER READING
    7. CHAPTER 10: COFACTORS
      1. 10.1 GENERAL ASPECTS
      2. 10.2 SPECIFIC BIOSYNTHETIC PATHWAYS
      3. 10.3 MEDICAL ASPECTS
      4. 10.4 BIOTECHNOLOGY
      5. REFERENCES
    8. CHAPTER 11: ANTIBIOTICS
      1. 11.1 BIOLOGY OF ANTIBIOTIC BIOSYNTHESIS
      2. 11.2 CHEMISTRY, ENZYMOLOGY, AND GENETICS OF ANTIBIOTIC BIOSYNTHESIS
      3. 11.3 TOOLS AND TECHNIQUES USED TO STUDY ANTIBIOTIC BIOSYNTHESIS
      4. REFERENCES
      5. FURTHER READING
  9. PART III: NATURAL PRODUCTS IN MEDICINE
    1. CHAPTER 12: PHARMACEUTICALS: NATURAL PRODUCTS AND NATURAL PRODUCT MODELS
      1. 12.1 INTRODUCTION
      2. 12.2 ANTIBACTERIAL AGENTS
      3. 12.3 ANTIFUNGAL AGENTS
      4. 12.4 ANTIMALARIALS
      5. 12.5 ANTIVIRALS
      6. 12.6 ANTIPAIN AGENTS
      7. 12.7 ANTIOBESITY
      8. 12.8 ALZHEIMER'S AGENTS
      9. 12.9 ANTINEOPLASTIC AGENTS
      10. 12.10 IMMUNOSUPPRESSANT AGENTS
      11. 12.11 CARDIOVASCULAR AGENTS
      12. 12.12 ANTIPARASITIC AGENTS
      13. 12.13 PHARMACEUTICAL MODELS
      14. REFERENCES
    2. CHAPTER 13: NATURAL PRODUCTS AS ANTICANCER AGENTS
      1. 13.1 OVERVIEW OF NATURAL PRODUCTS AS ANTICANCER AGENTS
      2. 13.2 COMPOUNDS THAT TARGET PROTEINS
      3. 13.3 COMPOUNDS THAT TARGET DNA OR RNA
      4. 13.4 CONCLUSIONS
      5. REFERENCES
      6. FURTHER READING
    3. CHAPTER 14: PLANT-DERIVED NATURAL PRODUCTS RESEARCH IN DRUG DISCOVERY
      1. 14.1 ANTICANCER AND ANTITUMOR COMPOUNDS
      2. 14.2 ANTI-HIV COMPOUNDS
      3. 14.3 ACTIVE COMPOUNDS ISOLATED FROM WELL-KNOWN FOLKLORIC MEDICINE
      4. 14.4 CONCLUSION
      5. 14.5 ACKNOWLEDGMENT
      6. REFERENCES
  10. INDEX