Nanoscale engineering of silk fibroin scaffold architecture to repair patient-specific cancer defects
L.W. Dunne, T.S. Iyyanki, C.E. Butler and A.B. Mathur, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Abstract
Bombyx mori silk fibroin (SF)-based scaffolds were engineered by modulating SF solution parameters. Three-dimensional (3D) scaffolds were fabricated, and microstructure and mechanical properties were characterized. Silk solution parameters of SF scaffolds such as SF solution concentration (0.91–3.33% (w/v)), filter size (0.22, 0.45, 100 µm), pH (4, 5.5, 7.4), and ion concentration (no PBS, 0.1× PBS, 1× PBS) were altered. SF solution particle size was measured using dynamic light scattering (DLS); ...
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