Nanostructures for Novel Therapy

Nanostructures for Novel Therapy

by Denisa Ficai, Alexandru Mihai Grumezescu
Released February 2017
Publisher(s): Elsevier
ISBN: 9780323461481

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Book description

Nanostructures for Novel Therapy: Synthesis, Characterization and Applications focuses on the fabrication and characterization of therapeutic nanostructures, in particular, synthesis, design, and in vitro and in vivo therapeutic evaluation. The chapters provide a cogent overview of recent therapeutic applications of nanostructured materials that includes applications of nanostructured materials for wound healing in plastic surgery and stem cell therapy.

The book explores the promise for more effective therapy through the use of nanostructured materials, while also assessing the challenges their use might pose from both an economic and medicinal point of view. This innovative look at how nanostructured materials are used in therapeutics will be of great benefit to researchers, providing a greater understanding of the different ways nanomaterials could improve medical treatment, along with a discussion of the obstacles that need to be overcome in order to guarantee widespread availability.

  • Outlines how the characteristics of nanostructures made from different materials gives particular properties that can be successfully used in therapeutics
  • Compares the properties of different nanostructures, allowing medicinal chemists and engineers to select which are most appropriate for their needs
  • Highlights new uses of nanostructures within the therapeutic field, enabling the discovery of new, more effective drugs

Table of contents

  1. Cover
  2. Title page
  3. Table of Contents
  4. Copyright
  5. List of Contributors
  6. Foreword of the Series
  7. Preface
  8. Chapter 1: Novel approaches for preparation of nanoparticles
    1. Abstract
    2. 1. Introduction
    3. 2. Synthetic Methods for Preparation of Metal Nanoparticles
    4. 3. Application of Metal Nanoparticles in Theranostics
    5. 4. Conclusions
    6. Acknowledgments
  9. Chapter 2: Applications of nanoscale drugs carriers in the treatment of chronic diseases
    1. Abstract
    2. 1. Introduction in Drug Delivery and Targeting
    3. 2. Applications of Nanotechnology in Drug Delivery and Targeting
    4. 3. Conclusions
  10. Chapter 3: Functionalization of nanoparticles in specific targeting and mechanism release
    1. Abstract
    2. 1. Introduction
    3. 2. Controlled-Release Mechanisms
    4. 3. Project of Nanoparticles
    5. 4. Nanoparticles Targeting
    6. 5. Conclusions
  11. Chapter 4: Fabrication and characterization of natural/synthesized, micro-, and nanostructured materials for biomedical applications
    1. Abstract
    2. 1. Introduction
    3. 2. Pearl Shell
    4. 3. Microstructure Analysis of Nacre by Transmission Electron Microscopy
    5. 4. Micro-/Nanoparticles
    6. 5. Surface Modification of Nanoparticles
    7. 6. 2D Periodic Structure by Thermal Imprinting Process
    8. 7. Functionalities for Biomedical Applications
    9. 8. Summary and Future Directions
  12. Chapter 5: Multifunctional nanostructured biopolymeric materials for therapeutic applications
    1. Abstract
    2. 1. Introduction
    3. 2. Biopolymers
    4. 3. Multifunctional Nanostructured Materials
    5. 4. Therapeutic Applications
    6. 5. Conclusions and Perspectives
  13. Chapter 6: Polymeric pharmaceutical nanoparticles developed by electrospray
    1. Abstract
    2. 1. Introduction
    3. 2. Polymeric Particles and Atomizers
    4. 3. Electrospray
    5. 4. Therapeutic Nanoparticles Loaded by Electrospray
    6. 5. Conclusions
  14. Chapter 7: Nanoformulation and administration of PUFA-rich systems for applications in modern healthcare
    1. Abstract
    2. 1. Introduction
    3. 2. Lipid Nanoparticles: Types and Fabrication Technology
    4. 3. Understanding the Physiological System for Therapy: The Significance of Lipid Nanotechnology at Tissue and Cellular Level
    5. 4. Therapeutic Lipid Nanostructures
    6. 5. Risk and Hazard Assessment
    7. 6. Challenges and Scope
    8. 7. Conclusions
    9. Acknowledgments
  15. Chapter 8: Electrospinning and surface modification methods for functionalized cell scaffolds
    1. Abstract
    2. 1. Electrospinning for Tissue Engineering
    3. 2. Fundamentals of the Electrospinning Process
    4. 3. Tuning the Morphology of Electrospun Scaffolds and its Effects on Cell Behavior
    5. 4. Surface Modification Methods of Electrospun Nanofibers
    6. 5. Conclusions
  16. Chapter 9: Short peptide self-assembled nanostructures for therapeutics innovative delivery
    1. Abstract
    2. 1. Introduction
    3. 2. Preparation and Characterization of Self-Assembling Short Peptides
    4. 3. Drug-Delivery Applications
    5. 4. Self-Assembly to Achieve a Therapeutic Effect
    6. 5. Conclusions and Future Outlook
    7. Abbreviations
  17. Chapter 10: Peptoids: tomorrow’s therapeutics
    1. Abstract
    2. 1. Introduction
    3. 2. Peptoid Synthesis
    4. 3. Peptoid Structures
    5. 4. Applications of Peptoids
    6. 5. Conclusions
  18. Chapter 11: Electrospinning of collagen nanofiber scaffolds for tissue repair and regeneration
    1. Abstract
    2. 1. Introduction
    3. 2. Tissue Engineering
    4. 3. Scaffold
    5. 4. Nanofibers
    6. 5. Electrospinning
    7. 6. Applications of Electrospun Collagen
  19. Chapter 12: Nanostructured therapeutic systems with bioadhesive and thermoresponsive properties
    1. Abstract
    2. 1. Introduction
    3. 2. Bioadhesive Systems
    4. 3. Stimuli-Responsive Polymers
    5. 4. Hydrogels
    6. 5. Mucoadhesive Thermoresponsive Systems
    7. 6. Characterization of Mucoadhesive Thermoresponsive Systems
    8. 7. Conclusions
  20. Chapter 13: Design considerations in the development of wound healing bionanomaterials
    1. Abstract
    2. 1. Introduction
    3. 2. Skin: Properties, Growth, and Regeneration
    4. 3. Bionanomaterials
    5. 4. Nanostructures
    6. 5. Nanofabrication
    7. 6. Conclusions
  21. Chapter 14: Role of nanostructure molecules in enhancing the bioavailability of oral drugs
    1. Abstract
    2. 1. Nanotechnology: Some Basic Concepts
    3. 2. Nanostructure Molecules or Nanoparticles
    4. 3. Absorption of Oral Drugs in the Gastrointenstinal Tract
    5. 4. Nanoscience and Nanotechnology: From Basic Science to Applications
  22. Chapter 15: Improvement steps of plastic surgery to tissue engineering by nanotechnology
    1. Abstract
    2. 1. Introduction
    3. 2. Development of Nanotechnology Into Nanomedicine
    4. 3. Nanomaterials Used in Medical Therapeutics
    5. 4. Nanotechnology in Diagnostics
    6. 5. Nanotechnology and Drug Delivery
    7. 6. Use of Nanotechnology in Tissue Engineering
    8. 7. Conclusions
  23. Chapter 16: Dendrimers and dendronized materials as nanocarriers
    1. Abstract
    2. 1. Introduction
    3. 2. Synthetic Approach
    4. 3. Physico-Chemical Properties of Dendritic Molecules useful for Nanocarriers
    5. 4. Drug–Dendritic Polymer Interactions
    6. 5. Types of Targeting by Nanodelivery System
    7. 6. Routes of Administration of Dendritic Molecules
    8. 7. Successful Examples of Dendritic Molecules as Nanocarriers
    9. 8. Conclusions
    10. Acknowledgments
  24. Chapter 17: Gold nanostructures: preparation, properties, application in SERS, and biophotonics
    1. Abstract
    2. 1. Introduction
    3. 2. Experimental
    4. 3. Theoretical
    5. 4. Methods for Preparation of Gold Nanoparticles and Nanostructures. Application in SERS
    6. 5. Application of Au Nanostructures in Biophotonics
    7. 6. Conclusions
    8. Acknowledgments
  25. Chapter 18: Quantum dots for bioimaging and therapeutic applications
    1. Abstract
    2. 1. Introduction
    3. 2. QDs for Bioimaging Applications
    4. 3. QDs for Therapy
    5. 4. Conclusions
  26. Chapter 19: Lipid-based synthetic gene carriers
    1. Abstract
    2. 1. Introduction
    3. 2. Equilibrium Lipoplex Structure on the Nanoscale
    4. 3. The Kinetics of Lipoplex Formation
    5. 4. Discussion
    6. 5. Conclusions
    7. Conflict of Interests
  27. Chapter 20: Using microsensors to promote the development of innovative therapeutic nanostructures
    1. Abstract
    2. 1. Introduction
    3. 2. Nano-Objects Definition and Properties
    4. 3. Integrated Analyte Handling
    5. 4. Measurements Techniques
    6. 5. Conclusions
  28. Chapter 21: The effect of nanostructured surfaces on stem cell fate
    1. Abstract
    2. 1. Introduction
    3. 2. Nanostructured Surfaces
    4. 3. Stem Cells within the Human Body and Their Use in Regenerative Medicine
    5. 4. Interactions of Nanostructured Surfaces and Stem Cells
    6. 5. Future Perspective
    7. Acknowledgments
  29. Chapter 22: Applications of aptamers for the diagnosis and therapy of different diseases
    1. Abstract
    2. 1. Introduction
    3. 2. Selection of Aptamers
    4. 3. Aptamers as Therapeutics
    5. 4. Challenges of Aptamers
    6. 5. Nanotechnology and Aptamers
    7. 6. Conclusions
  30. Chapter 23: Recent progress in therapeutic diagnosis using photonic crystal nanostructures
    1. Abstract
    2. 1. Introduction to Photonic Crystal Nanostructures
    3. 2. Origin of Photonic Bandgap
    4. 3. Photonic Crystal Slabs
    5. 4. Materials and Fabrication Methods
    6. 5. Introduction to Biosensors
    7. 6. PC Laser Biosensors and Lab-on-Chip Devices
    8. 7. Conclusions
  31. Chapter 24: Novel carriers and approaches: insight for psoriasis management
    1. Abstract
    2. 1. Introduction
    3. 2. Types of Psoriasis
    4. 3. Pathogenesis of Psoriasis
    5. 4. Function of Cytokines
    6. 5. Treatment Approaches for Psoriasis
    7. 6. Novel Colloidal Carriers for Psoriasis Treatment
    8. 7. Lipid-Based Particulate Carriers
    9. 8. Emulsion-Based Carriers
    10. 9. Conclusions
  32. Chapter 25: Use of nanostructures based on noble metals in nanobiomedicine
    1. Abstract
    2. 1. Introduction
    3. 2. Optical Properties of Metal Nanostructures
    4. 3. Applications in Biological Systems and Biomedicine
    5. 4. Summary
  33. Chapter 26: Innovative nonviral vectors for small-interfering RNA delivery and therapy
    1. Abstract
    2. 1. Introduction
    3. 2. Obstacles to In Vivo siRNA Delivery: The Biological Barriers and the Immunological Response
    4. 3. Chemical Modifications of siRNA
    5. 4. siRNA Delivery Systems: Focus on Liposomes and Lipoplexes
    6. 5. Clinical Trials
    7. 6. Conclusions
  34. Chapter 27: siRNA-based nucleoceuticals for tissue regeneration
    1. Abstract
    2. 1. Introduction
    3. 2. Heart Regeneration
    4. 3. Kidney Regeneration
    5. 4. Liver Regeneration
    6. 5. Ocular Regeneration
    7. 6. Peritoneal Fibrosis Regeneration
    8. 7. Cartilage Regeneration
    9. 8. Skin Regeneration
    10. 9. Bone Regeneration
    11. 10. Nerve Regeneration
    12. 11. Conclusions
  35. Chapter 28: Bone tissue regenerative medicine via bioactive nanomaterials
    1. Abstract
    2. 1. Introduction
    3. 2. Synthetic Approaches for Bone Tissue Replacement
    4. 3. Nanomaterials as key Enablers of Bone Regeneration
    5. 4. Risks and Obstacles of Nanomaterials Applications
    6. 5. Perspectives and Outlooks
    7. Acknowledgments
  36. Chapter 29: Toxicity of nanostructures—a general approach
    1. Abstract
    2. 1. Introduction
    3. 2. Metallic Nanostructures
    4. 3. Nonmetallic Nanostructures
    5. 4. Conclusions
  37. Chapter 30: Role of Excipients in formulation development and biocompatibility of lipid nanoparticles (SLNs/NLCs)
    1. Abstract
    2. 1. Introduction
    3. 2. Role of Excipients in SLNs and NLCs
    4. 3. Conclusions
    5. Acknowledgment
  38. Index

Product information

  • Title: Nanostructures for Novel Therapy
  • Author(s): Denisa Ficai, Alexandru Mihai Grumezescu
  • Release date: February 2017
  • Publisher(s): Elsevier
  • ISBN: 9780323461481