You can divided the InnoDB buffer pool into separate regions to improve concurrency, by reducing contention as different threads read and write to cached pages. For example, if the buffer pool size is 64 GB and innodb_buffer_pool_instances are 32, the buffer is split into 32 regions with 2 GB each.
If the buffer pool size is more than 16 GB, you can set the instances so that each region gets at least 1 GB of space.
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