Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods

7.4 Further Considerations on MCP-Mod

The original MCP-Mod procedure from Bretz et al. was motivated by the work of Tukey et al., who proposed to use several trend tests simultaneously based on different functional dose-response descriptions and subsequently to adjust the resulting p-values for multiplicity [2,13]. Since then, the methodology has been the subject of several investigations. Thomas and Wakana et al. investigated extensions to Bayesian methods for estimating or selecting the dose-response curve from a sparse dose design [14,15]. Klingenberg applied the MCP-Mod approach to proof-of-concept studies with binary responses [16]. Benda proposed a time-dependent dose finding approach with repeated binary data [17]. Akacha and Benda investigated ...