2.4 Types of Stopping Boundaries
2.4.1 Calculation of Stopping Boundaries
We have provided an
overview of the distributional theory of sequential testing in the
previous section. This section focuses on the calculation of stopping
boundaries. Based on the specified hypotheses, stopping boundaries
can be either one-sided or two-sided. In addition, depending on the
prospective outlook of the trial, investigators can specify if the
set of boundaries is to (1) reject the null hypothesis (
), (2) reject either the null hypothesis (
), or the alternative ...
), (2) reject either the null hypothesis (), or the alternative ...Get Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods now with the O’Reilly learning platform.
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