6.4 Analysis Examples Using Simulated Data
6.4.1 Brief Introduction to the Emax Model
This section describes two simulated practical examples for continuous and binary
endpoints. The simulated data assume that there are 5 dose groups, 0mg (placebo),
2.5mg, 5mg, 10mg, and 20mg, in a phase II dose ranging trial. The sample size in each
dose group is 60. The 
models to analyze the data. Note that
nlmixed
procedure is used to fit 4-parameter models to analyze the data. Note that proc
nlin in SAS could be used to fit the 4-parameter model as well, which is dedicated to the nonlinear regression model. Both procedures produce very similar estimates and results. In addition, code for trend ...Get Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods now with the O’Reilly learning platform.
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