9.6 Summary
This chapter reviews
various types of adaptive-randomization designs in clinical trials.
When used appropriately, adaptive designs may improve the efficiency
and reduce the cost of a trial. Also, the information from the recruited
patients can be maximally utilized, and the risk to the patients can
be substantially reduced.
However, in practice,
randomized trials are still dominated by the conventional fixed-randomization
scheme due to the following concerns:
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Patients may not be balanced on certain covariates, especially those with possible time trends.
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Hypothesis tests during interim monitoring and at the trial completion are unconventional and difficult.
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Delayed outcomes may affect the practical implementation of ...
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