5.5 Time-to-Event Continual Reassessment Method
Using patients' exposure times as weights, Cheung and Chappell [12] proposed the time-to-event
continual reassessment method (TITE-CRM) to incorporate information of follow-up times
into toxicity evaluation. Let 
be the actual follow-up time for subject 
, and let 
be the observed toxicity outcome at time . If the th patient has not experienced the DLT, takes a value of 0, and otherwise =1. Often a uniform ...
be the actual follow-up time for subject , and let be the observed toxicity outcome at time . If the th patient has not experienced the DLT, takes a value of 0, and otherwise =1. Often a uniform ...Get Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods now with the O’Reilly learning platform.
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