10.7 Examples

10.7.1 Redesigning a Real Clinical Trial

In this section we give an example of a published clinical trial where an optimal RAR design could be useful. Connor and co-authors in [66] reported the results of a randomized, double-blind, placebo-controlled trial of the efficacy and safety of zidovudine (AZT) in reducing the risk of maternal-infant transmission of the human immunodeficiency virus (HIV) type 1. In this trial, 477 pregnant women were enrolled and randomized equally between AZT open . n sub e , equals 239 . close and a placebo open . n sub c , equals 238 . close. In the study, 409 women gave birth ...

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