Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods

About This Book

Purpose

Modern Approaches to Clinical Trials Using SAS®: Classical, Adaptive, and Bayesian Methods is unique and multifaceted, covering several domains of modern clinical trial design, including classical, group sequential, adaptive, and Bayesian methods that are applicable to and widely used in various phases of pharmaceutical development. Topics covered include, but are not limited to, dose-response and dose-escalation designs; sequential methods to stop trials early for overwhelming efficacy, safety, or futility; Bayesian designs that incorporate historical data; adaptive sample size re-estimation; adaptive randomization to allocate subjects to more effective treatments; and population enrichment designs. Methods are illustrated ...