Medicinal Chemistry, 2nd Edition

Chapter 7

Sedatives, Hypnotics, and Anxiolytic Agents

LEARNING OBJECTIVES

• Define insomnia and various causes of insomnia

• Define sedation and hypnotics

• List the classes of sedatives and hypnotics

• Categorize barbiturates based on the duration of action

• Describe various benzodiapine classes of drugs useful as sedatives and hypnotics

• Describe the discovery of barbiturates

• Describe how barbiturates act on the CNS to deliver sedation and hypnosis

• Describe the methods of preparation of all barbiturates

• Describe the relationship between structure of barbiturates and their biological activity

• Learn the discovery pathway of benzodiazepines

• Define the mechanism behind the action of benzodiazepines as sedatives

• Describe the utility of Friedel-Crafts ...