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Medical Advancements in Aging and Regenerative Technologies

Book Description

Studies of developmental biology are now benefiting the advancements made in the field of regenerative medicine. Current research on aging will attempt to reverse visible aging characteristics of somatic cells using cellular reprogramming to by-pass senescence. Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications aims to translate basic science discoveries into regenerative therapies with the application of clinical tool in aging and tissue regeneration. The understanding of the characteristics affecting the aging process is an effort to guide approaches for preventing and treating age-related diseases. 

Table of Contents

  1. Cover
  2. Title Page
  3. Copyright Page
  4. Editorial Advisory Board and List of Reviewers
    1. Editorial Advisory Board
  5. Foreword
  6. Preface
    1. OBJECTIVE OF THE BOOK
    2. ORGANIZATION OF THE BOOK
  7. Section 1: Aging and Regeneration: Basic Concepts in Medicine
    1. Chapter 1: BMP Signaling in Regenerative Medicine
      1. ABSTRACT
      2. INTRODUCTION
      3. BACKGROUND
      4. FUTURE RESEARCH DIRECTIONS
      5. CONCLUSION
    2. Chapter 2: Proliferation and Regeneration
      1. ABSTRACT
      2. INTRODUCTION
      3. TUMOR ONTOGENESIS
      4. SOME CONCEPTS OF STEM CELL BIOLOGY
      5. ESSENTIALS ON STEM CELL TREATMENT
      6. TISSUE REGENERATION MECHANISMS
      7. REGENERATION METHODOLOGIES IN CANCER TREATMENT
      8. REGENERATION VS. PROLIFERATION AND CONTROVERSIES
    3. Chapter 3: Modeling Colorectal Cancer
      1. ABSTRACT
      2. INTRODUCTION
      3. STABILITY ANALYSIS
      4. CONCLUSION
    4. Chapter 4: Gene Expression Regulation underlying Osteo-, Adipo-, and Chondro-Genic Lineage Commitment of Human Mesenchymal Stem Cells
      1. ABSTRACT
      2. INTRODUCTION
      3. MATERIALS AND METHODS
      4. RESULTS
      5. DISCUSSION
  8. Section 2: Basic Research: A Bridge between Aging and Regeneration
    1. Chapter 5: Immunogenicity of Stem Cells
      1. ABSTRACT
      2. INTRODUCTION
      3. TOTIPOTENCY/PLURIPOTENCY/MULTIPOTENCY
      4. IMMUNOBIOLOGY OF EMBRYONIC STEM CELLS
      5. INNATE IMMUNE SYSTEM
      6. STRATEGIES TO OVERCOME IMMUNOLOGICAL BARRIERS
      7. CONCLUSION
    2. Chapter 6: Regulatory T Cell-Based Immunotherapy
      1. ABSTRACT
      2. INTRODUCTION
      3. PERIPHERAL REGULATORY T CELL INDUCTION IN VIVO
      4. PERIPHERAL TREG CELL INDUCTION IN THE STEADY STATE
      5. HELIOS: A MARKER TO DISTINGUISH TREG CELLS OF THYMIC AND PERIPHERAL ORIGIN?
      6. THYMIC CONTRIBUTION TO PERIPHERAL TREG CELL INDUCTION
      7. PERIPHERAL TREG CELL INDUCTION FROM SELF-REACTIVE CD4+ T CELLS
      8. CONCLUDING REMARKS
    3. Chapter 7: Regeneration of Articular Cartilage
      1. ABSTRACT
      2. INTRODUCTION
      3. STRUCTURE AND FUNCTION OF ARTICULAR CARTILAGE
      4. CARTILAGE DEGENERATION IN OSTEOARTHRITIS (OA)
      5. CARTILAGE REGENERATION AND REPAIR
      6. BONE MARROW STIMULATION TECHNIQUES
      7. CELL-BASED REPAIR STRATEGIES
      8. MESENCHYMAL STEM CELLS (MSCS)
      9. BIOMIMETIC AND TISSUE ENGINEERED MODELS OF ARTICULAR CARTILAGE
      10. CARTILAGE AND OSTEOCHONDRAL EXPLANTS
      11. PERSPECTIVES AND CONCLUDING REMARKS
    4. Chapter 8: Generation of Scaffold Free 3-D Cartilage-Like Microtissues from Human Chondrocytes
      1. ABSTRACT
      2. INTRODUCTION
      3. BACKGROUND
      4. MAIN FOCUS OF THE CHAPTER
      5. EXPERIMENTAL OUTLINE: SOLUTIONS AND RECOMMENDATIONS
      6. DISCUSSION
    5. Chapter 9: The Hidden Markov Brains
      1. ABSTRACT
      2. INTRODUCTION
      3. VASCULAR DEPRESSION HYPOTHESIS
      4. CARDIAC PHYSIOLOGY IN DEPRESSION
      5. HIDDEN MARKOV MODELS OF THE BRAIN ON MRI
      6. CONCLUSION
  9. Section 3: Regeneration and Aging: Applications in Medicine and Dentistry
    1. Chapter 10: Designing Biomedical Stents for Vascular Therapy
      1. ABSTRACT
      2. INTRODUCTION
      3. ETIOLOGY OF VASCULAR STENT RELATED PROBLEMS
      4. CURRENT STATUS OF STENT TECHNOLOGY
      5. POTENTIAL AND LIMITATIONS OF THE EXISTING TECHNOLOGY
      6. EMERGENCE OF STENT TECHNOLOGY WITH TRANSIENT NATURE: BIORESORBABLE STENT
      7. SURFACE COATED STENT: AN EVOLVING TECHNOLOGY
      8. FUTURE DIRECTIONS: BIOACTIVE STENTS
      9. CONCLUSION
    2. Chapter 11: Heart Valve Diseases in the Elderly
      1. ABSTRACT
      2. AN OVERVIEW
      3. ANATOMIES OF THE HEART AND VALVES
      4. THE EFFECT OF AGING ON THE HEART AND ITS VALVES
      5. THE PROJECTION OF OLDER POPULATION
      6. VALVULAR HEART DISEASES (VHD)
      7. AORTIC REGURGITATION (AR)
      8. DETECTION OF VALVULAR HEART DISEASE
      9. TREATMENT OF HEART VALVE DISEASES
      10. FINAL REMARKS AND FUTURE DEVELOPMENT
    3. Chapter 12: Tactile Resonance Sensors for Detection and Diagnosis of Age-Related Diseases
      1. ABSTRACT
      2. INTRODUCTION
      3. BACKGROUND
      4. USE OF RESONANCE SENSORS FOR DETECTION OF EYE PRESSURE AND PROSTATE CANCER
      5. FUTURE RESEARCH DIRECTIONS
      6. CONCLUSION
    4. Chapter 13: Dental Tissue Engineering Research and Translational Approaches towards Clinical Application
      1. ABSTRACT
      2. INTRODUCTION
      3. STEM CELL RESEARCH IN DENTAL TISSUE ENGINEERING: STATE OF THE SCIENCE
      4. STEM CELL-BASED THERAPY FOR DENTAL TISSUE/WHOLE TOOTH ENGINEERING
      5. CONCLUSION AND FUTURE PERSPECTIVES
    5. Chapter 14: Can Activated Platelet Rich Plasma Combined with Adipose-Derived Stem Cells Be Used to Treat Skin Wrinkles?
      1. ABSTRACT
      2. INTRODUCTION
      3. ADSC ISOLATION AND VIABILITY
      4. ISOLATION AND CULTURE OF DERMAL FIBROBLAST
      5. PRP PREPARATION
      6. IN VITRO EFFECT OF ADSC AND FIBROBLAST CO-CULTURES SUPPLEMENTED WITH PRP
      7. IN VIVO EFFECT OF COMBINED ADSCS / PRP INJECTION ON PHOTO-AGED MOUSE MODELS
      8. DISCUSSION
      9. CONCLUSION
  10. Appendix A
  11. Appendix B
  12. Appendix C
  13. Appendix D
  14. Appendix E
  15. Appendix F
  16. Appendix G
  17. Appendix H
  18. Appendix I
  19. Compilation of References
  20. About the Contributors