Ready to use technologies and their role in Lean biomanufacturing
Abstract:
This chapter reviews various technologies which help to promote the implementation of a Lean biomanufacturing approach including key points like lead time reduction, cycle time reduction and cycle smoothing. The contribution of disposable systems to Lean manufacturing is highlighted including the possibilities for mistake-proofing, reduced start up costs, short cycle times and zero cleaning validation. The examples include upstream and downstream case studies. Key influences like leachables and extractables are also discussed and how these can be minimized.
Key words
recovery performance
expanded bed
protein affinity quality attributes
leachables and extractables ...
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