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Epigenetics in Health and Disease by Olga Kovalchuk Ph.D., MD, Igor Kovalchuk Ph.D., MD

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20. Epigenetics and technology—hairpin-based antisensing

RNA interference, known as RNAi, is a fascinating phenomenon that enables us to understand how organisms control expression of endogenous and exogenous RNAs. Moreover, RNAi represents a powerful research and therapeutic tool for the regulation of gene expression in cells. The use of RNAi in functional genomics makes it possible to analyze the function of a specific gene. Its use in agriculture represents the knockdown of specific genes and the pathways for either removing an undesirable trait or adding a new, desirable one. The landmark discovery of the hairpin RNAi construct as an efficient sequence-dependent trigger of gene silencing provided a foundation for a new RNAi technology. This ...

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