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Epigenetics in Health and Disease by Olga Kovalchuk Ph.D., MD, Igor Kovalchuk Ph.D., MD

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18. Epigenetics of health and disease—behavioral neuroscience

The new discipline of epigenetics is of special interest to neuroscientists because it can provide a molecular basis for the complex mechanisms underlying cognition and behavior. In recent years, more and more research has been providing evidence that neurological processes are indeed regulated by epigenetic components: DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs. Neurological processes orchestrated by epigenetics include neuron development and function, neuronal plasticity, and memory formation just to name a few.

DNA methylation and brain

During brain development, DNA methylation is believed to be important in regulating the proliferation of neural ...

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