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Epigenetics in Health and Disease by Olga Kovalchuk Ph.D., MD, Igor Kovalchuk Ph.D., MD

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7. Non-coding RNAs involved in epigenetic processes: A general overview

Chapter 6, “Realm of Non-Coding RNAs: From Bacteria to Human,” introduced various non-coding RNAs (ncRNAs), attempted to classify them, and described some of their basic roles in the cell. This chapter specifically focuses on the role of ncRNAs in epigenetic processes, such as transcriptional and post-transcriptional gene silencing, imprinting, and regulating heritable responses to changing environmental conditions.

Since their discovery, small regulatory RNA species have been revealed to play major roles in gene regulation of most eukaryotic organisms (Vaucheret, 2006). They have been shown to have essential functions from embryonic development through sexual maturity in ...

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