Book description
Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology discusses the latest developments in all aspects of computational biology, bioinformatics, and systems biology and the application of data-analytics and algorithms, mathematical modeling, and simu- lation techniques.
• Discusses the development and application of data-analytical and theoretical methods, mathematical modeling, and computational simulation techniques to the study of biological and behavioral systems, including applications in cancer research, computational intelligence and drug design, high-performance computing, and biology, as well as cloud and grid computing for the storage and access of big data sets.
• Presents a systematic approach for storing, retrieving, organizing, and analyzing biological data using software tools with applications to general principles of DNA/RNA structure, bioinformatics and applications, genomes, protein structure, and modeling and classification, as well as microarray analysis.
• Provides a systems biology perspective, including general guidelines and techniques for obtaining, integrating, and analyzing complex data sets from multiple experimental sources using computational tools and software. Topics covered include phenomics, genomics, epigenomics/epigenetics, metabolomics, cell cycle and checkpoint control, and systems biology and vaccination research.
• Explains how to effectively harness the power of Big Data tools when data sets are so large and complex that it is difficult to process them using conventional database management systems or traditional data processing applications.
- Discusses the development and application of data-analytical and theoretical methods, mathematical modeling and computational simulation techniques to the study of biological and behavioral systems.
- Presents a systematic approach for storing, retrieving, organizing and analyzing biological data using software tools with applications.
- Provides a systems biology perspective including general guidelines and techniques for obtaining, integrating and analyzing complex data sets from multiple experimental sources using computational tools and software.
Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Acknowledgments
- Introduction
- Chapter 1: Supervised Learning with the Artificial Neural Networks Algorithm for Modeling Immune Cell Differentiation
- Chapter 2: Accelerating Techniques for Particle Filter Implementations on FPGA
- Chapter 3: Biological Study on Pulsatile Flow of Herschel-Bulkley Fluid in Tapered Blood Vessels
- Chapter 4: Hierarchical k-Means: A Hybrid Clustering Algorithm and Its Application to Study Gene Expression in Lung Adenocarcinoma
- Chapter 5: Molecular Classification of N-Aryloxazolidinone-5-carboxamides as Human Immunodeficiency Virus Protease Inhibitors
- Chapter 6: Review of Recent Protein-Protein Interaction Techniques
- Chapter 7: Genetic Regulatory Networks: Focus on Attractors of Their Dynamics
- Chapter 8: Biomechanical Evaluation for Bone Allograft in Treating the Femoral Head Necrosis: Thorough Debridement or not?
-
Chapter 9: Diels-Alderase Catalyzing the Cyclization Step in the Biosynthesis of Spinosyn A: Reality or Fantasy?
- Abstract
- Acknowledgments
- Graphical Abstract
- 1 Introduction
- 2 Computational methods
- 3 Results and discussion
- 4 Conclusions
- Supplementary Material: Diels-Alderase Catalyzing the Cyclization Step in the Biosynthesis of Spinosyn A: Reality or Fantasy?
- 1 Conformational analysis of macrocyclic lactone (4)
- 2 Modelling of a theozyme for the conversion of macrocyclic lactone (4) into tricyclic compound (5)
- 3 ELF bonding analysis of the conversion of macrocyclic lactone (4) into the tricyclic compound (5)
- Chapter 10: CLAST: Clustering Biological Sequences
- Chapter 11: Computational Platform for Integration and Analysis of MicroRNA Annotation
- Chapter 12: Feature Selection and Analysis of Gene Expression Data Using Low-Dimensional Linear Programming
-
Chapter 13: The Big ORF Theory: Algorithmic, Computational, and Approximation Approaches to Open Reading Frames in Short- and Medium-Length dsDNA Sequences
- Abstract
- Acknowledgments
- 1 Introduction
- 2 Molecular genetic and bioinformatic considerations
- 3 Algorithmic and programming considerations
- 4 Analytical and random sampling solutions to L > 25 sequences: Triplet-based approximations
- 5 Alternative genetic codes
- 6 Implications for the evolution of ORF size
- Chapter 14: Intentionally Linked Entities: A Detailed Look at a Database System for Health Care Informatics
- Chapter 15: Region Growing in Nonpictorial Data for Organ-Specific Toxicity Prediction
- Chapter 16: Contribution of Noise Reduction Algorithms: Perception Versus Localization Simulation in the Case of Binaural Cochlear Implant (BCI) Coding
- Chapter 17: Lowering the Fall Rate of the Elderly from Wheelchairs
-
Chapter 18: Occipital and Left Temporal EEG Correlates of Phenomenal Consciousness
- Abstract
- Acknowledgments
- 1 Introduction
- 2 Participants
- 3 Apparatus and stimuli
- 4 Procedure
- 5 EEG recording
- 6 Experiment I
- 7 Experiment II
- 8 The grand average occipital and temporal electrical activity correlated with a contrast in access
- 9 Behavioral data
- 10 The grand average occipital and temporal electrical activity correlated with a contrast in phenomenology
- 11 The grand average occipital and temporal electrical activity co-occurring with unconsciousness
- Chapter 19: Chaotic Dynamical States in the Izhikevich Neuron Model
- Chapter 20: Analogy, Mind, and Life
-
Chapter 21: Copy Number Networks to Guide Combinatorial Therapy of Cancer and Proliferative Disorders
- Abstract
- Acknowledgments
- 1 Introduction
- 2 A diminishing drug pipeline
- 3 Using genome data to replenish the pipeline by drug repositioning
- 4 The small-world properties of networks expedite combination therapies
- 5 Molecular networks can be used to guide drug combinations
- 6 Copy number alterations as a disease driver
- 7 Using correlated copy number alterations to construct survival networks
- 8 A pan-cancer CNA interaction network
- 9 Mapping genetic survival networks using correlated CNAs in radiation hybrid cells
- 10 A survival network for GBM at single-gene resolution
- 11 Using CNA networks to guide combination therapies
- 12 Targeting multiple drugs to single-disease genes in cancer
- 13 Targeting multiple drugs to a single-disease gene in autoimmunity
- 14 Targeting multiple genes in a single pathway for cancer
- 15 Targeting genes in parallel pathways converging on atherosclerosis
- 16 Using CNA networks to synergize drug combinations and minimize side effects
- 17 Disclaimer
- Chapter 22: DNA Double-Strand Break–Based Nonmonotonic Logic
- Chapter 23: An Updated Covariance Model for Rapid Annotation of Noncoding RNA
- Chapter 24: SMIR: A Web Server to Predict Residues Involved in the Protein Folding Core
- Chapter 25: Predicting Extinction of Biological Systems with Competition
- Chapter 26: Methodologies for the Diagnosis of the Main Behavioral Syndromes for Parkinson’s Disease with Bayesian Belief Networks
-
Chapter 27: Practical Considerations in Virtual Screening and Molecular Docking
- Abstract
- 1 Introduction
- 2 Receptor structure preparation
- 3 Accurately predicting the pose of solved crystal structures and differentiating decoys from actives
- 4 Side-chain flexibility and ensemble docking
- 5 Consensus docking
- 6 MM-GBSA
- 7 Incorporating pharmacophoric constraints within the virtual screen
- 8 Conclusion
- Chapter 28: Knowledge Discovery in Proteomic Mass Spectrometry Data
- Chapter 29: A Comparative Analysis of Read Mapping and Indel Calling Pipelines for Next-Generation Sequencing Data
- Chapter 30: Two-Stage Evolutionary Quantification of In Vivo MRS Metabolites
- Chapter 31: Keratoconus Disease and Three-Dimensional Simulation of the Cornea throughout the Process of Cross-Linking Treatment
-
Chapter 32: Emerging Business Intelligence Framework for a Clinical Laboratory Through Big Data Analytics
- Abstract
- 1 Introduction
- 2 Motivation
- 3 Material and methods
- 4 Use-cases
- 5 Case Study 1: Clinical laboratory test usage patterns visualization
- 6 Data source and methodology
- 7 Results and discussion
- 8 Limitations
- 9 Case Study 2: Provincial laboratory clinical test volume estimation
- 10 Data source and methodology
- 11 Results and discussion
- 12 Limitations
- 13 Conclusion and future work
- Chapter 33: A Codon Frequency Obfuscation Heuristic for Raw Genomic Data Privacy
- Index
Product information
- Title: Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology
- Author(s):
- Release date: August 2015
- Publisher(s): Morgan Kaufmann
- ISBN: 9780128026465
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