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Early Detection and Rehabilitation Technologies for Dementia

Book Description

Dementia is a progressive neurodegenerative disease, of which Alzheimer’s disease (AD) is the most frequent cause. AD is characterized by the progressive formation of insoluble amyloid plaques and vascular deposits of amyloid beta peptide in the brain. AD patients suffer from a loss of neurons and synapses in the cerebral cortex and certain sub-cortical regions.Early Detection and Rehabilitation Technologies for Dementia: Neuroscience and Biomedical Applications provides a comprehensive collection for experts in the Neuroscience and Biomedical technology fields. Outlining various concepts from cognitive neuroscience and dementia to neural technology and rehabilitation; this book proves to bring together researchers and practitioners from diverse fields, in order to promote scientific research and industrial development in the field of early detection and rehabilitation technology of dementia. 

Table of Contents

  1. Cover
  2. Title Page
  3. Copyright Page
  4. Editorial Advisory Board and List of Reviewers [Chapter Title]
    1. EDITORIAL ADVISORY BOARD
    2. LIST OF REVIEWERS
  5. Preface
  6. Section 1:
    1. Chapter 1: The Relationship between Visual Interpolation Ability and Leukoaraiosis in Healthy Subjects
      1. ABSTRACT
      2. INTRODUCTION
      3. EXPERIMENT
      4. RESULTS
      5. DISCUSSION
    2. Chapter 2: Integrative fMRI-MEG Methods and Optically Pumped Atomic Magnetometers for Exploring Higher Brain Functions
      1. ABSTRACT
      2. INTRODUCTION
      3. INTEGRATIVE FMRI-MEG NEUROIMGING
      4. HIGH-SENSITIVITY ATOMIC MAGNETOMETERS
      5. CONCLUSION
    3. Chapter 3: Location and Functional Definition of Human Visual Motion Organization Using Functional Magnetic Resonance Imaging
      1. ABSTRACT
      2. INTRODUCTION
      3. EXPERIMENT
      4. RESULTS
      5. DISCUSSION
      6. CONCLUSION
    4. Chapter 4: Visual Attention with Auditory Stimulus
      1. ABSTRACT
      2. INTRODUCTION
      3. ATTENTION
      4. EXPERIMENT
      5. RESULTS
      6. DISCUSSION
      7. CONCLUSION
    5. Chapter 5: Cerebral Network for Implicit Chinese Character Processing
      1. ABSTRACT
      2. INTRODUCTION
      3. LANGUAGE
      4. EXPERIMENT
      5. RESULTS
      6. DISCUSSION
    6. Chapter 6: Neuronal Substrates for Language Processing and Word Priming
      1. ABSTRACT
      2. INTRODUCTION
      3. WORD PROCESSING
      4. PRIMING EFFECT
      5. EXPERIMENT
      6. RESULTS AND DISCUSSION
      7. DISCUSSION
    7. Chapter 7: Visual Gnosis and Face Perception
      1. ABSTRACT
      2. ANATOMY AND PHYSIOLOGY OF THE VISUAL PATHWAYS
      3. FACE PERCEPTION
      4. THE P100 COMPONENT
      5. THE N170 COMPONENT
      6. LATE COMPONENTS IN THE TIME WINDOW OF 270-390 MS
      7. GENERAL DISCUSSION
    8. Chapter 8: Human Characteristics of Sound Localization under Masking for the Early Detection of Dementia
      1. ABSTRACT
      2. INTRODUCTION
      3. SOUND LOCALIZATION
      4. MASKING
      5. EXPERIMENT
      6. RESULTS AND DISCUSSION
    9. Chapter 9: Kinetic Visual Field with Changing Contrast and Brightness
      1. ABSTRACT
      2. INTRODUCTION
      3. STATIC AND KINETIC VISUAL FIELDS
      4. VISUAL FIELD AND ALZHEIMER’S DISEASE
      5. EXPERIMENT
      6. RESULTS
      7. DISCUSSION
    10. Chapter 10: Effects of Stimulus Complexity on Bisensory Audiovisual Integration
      1. ABSTRACT
      2. INTRODUCTION
      3. EXPERIMENT
      4. RESULTS
      5. DISCUSSION
    11. Chapter 11: Tactile Pattern Delivery Device to Investigate Cognitive Mechanisms for Early Detection of Alzheimer’s Disease
      1. ABSTRACT
      2. INTRODUCTION
      3. DEVELOPMENT OF AN MRI-COMPATIBLE DELIVERY DEVICE
      4. DEVELOPMENT OF A PASSIVELY TACTILE PATTERN DELIVERY DEVICE FOR PSYCHOLOGICAL EXPERIMENTS
      5. EVALUATION EXPERIMENT
      6. CONCLUSION
    12. Chapter 12: Prospective Memory Impairment in Remembering to Remember in Mild Cognitive Impairment and Healthy Subjects
      1. ABSTRACT
      2. INTRODUCTION
      3. METHOD
      4. RESULTS
      5. DISCUSSION
    13. Chapter 13: Cognitive Decline in Patients with Alzheimer’s Disease
      1. ABSTRACT
      2. INTRODUCTION
      3. METHODS
      4. RESULTS
      5. DISCUSSION
    14. Chapter 14: The Clinical Analysis of Combined Effects of Huperzine A and Memantine for Alzheimer's Disease
      1. ABSTRACT
      2. INTRODUCTION
      3. EXPERIMENT
      4. RESULTS
      5. DISCUSSION
  7. Section 2:
    1. Chapter 15: From Bench to Bedside
      1. I. ABSTRACT
      2. II. DISCOVERY AND CLONING OF BACE1
      3. III. PATHOLOGY OF BACE1 IN AD BRAINS
      4. IV. CLINICAL CSF STUDIES WITH BACE1 IN ALZHEIMER’S DISEASE
      5. V. PERSPECTIVES OF NEUROCHEMICAL BIOMARKER DEVELOPMENT IN ALZHEIMER’S DISEASE
    2. Chapter 16: Aβ Monomer, Oligomer and Fibril in Alzheimer’s Disease
      1. ABSTRACT
      2. I. INTRODUCTION
      3. II. A FAMILIAL CASE WITH THE EARLY ONSET ALZHEIMER’S DISEASE
      4. III. BEYOND AMYLOID PLAQUES
      5. IV. PERSPECTIVE
    3. Chapter 17: The Value of Quantitative EEG Measures in the Early Diagnosis of Alzheimer’s Disease
      1. ABSTRACT
      2. INTRODUCTION
      3. METHOD
      4. RESULTS
      5. DISCUSSION
    4. Chapter 18: Apraxia
      1. ABSTRACT
      2. I. INTRODUCTION
      3. II. CLINICAL CONDITIONS
      4. III. CLINICAL ISSUES
      5. IV. TREATMENT
    5. Chapter 19: Pharmacokinetic Challenges against Brain Diseases with PET
      1. ABSTRACT
      2. INTRODUCTION
      3. STANDARD UPTAKE VALUE (SUV)
      4. CBF AND CMRO2 USING 15O2 AND H215O SUBJECTS
      5. DUAL INJECTION STUDY FOR CBF AND CMRO2
      6. 18F-FDOPA MODEL
      7. REFERENCE TISSUE MODEL
      8. APPROACH FOR NEURORECEPTOR COMPETITION STUDY
      9. CONCLUSION
    6. Chapter 20: Motion Perception in Healthy Humans and Cognitive Disorders
      1. ABSTRACT
      2. INTRODUCTION
      3. METHODS
      4. RESULTS AND DISCUSSION
      5. CONCLUSION
    7. Chapter 21: Neuronal Transcytosis of WGA Conjugated Protein
      1. ABSTRACT
      2. INTRODUCTION
      3. MATERIALS AND METHODS
      4. RESULTS
      5. DISCUSSION
    8. Chapter 22: Functional Optical Hemodynamic Imaging of the Olfactory Cortex in Patients with Parkinson’s Disease
      1. ABSTRACT
      2. INTRODUCTION
      3. MATERIALS AND METHODS
      4. RESULTS
      5. DISCUSSION
    9. Chapter 23: Basic Study on the Effect of Scent on Arousal Level Using Multi-Channel Near-Infrared Spectroscopy (MNIRS)
      1. ABSTRACT
      2. INTRODUCTION
      3. EXPERIMENTAL PROCEDURE
      4. TASTE FOR SCENT
      5. EXPERIMENTAL RESULTS ON THE DRIVING SIMULATOR
      6. EXPERIMENTAL RESULTS ON SEATING CONDITIONS
      7. SENTS ADOPTABLE FOR EACH SUBJECT
      8. 7. CONCLUSION
    10. Chapter 24: A Speech Prosody-Based Approach to Early Detection of Cognitive Impairment in Elderly Subjects
      1. ABSTRACT
      2. INTRODUCTION
      3. METHOD
      4. MEASUREMENT
      5. RESULTS AND DISCUSSION
      6. CONCLUSION AND FUTURE WORK
    11. Chapter 25: Non-Linear Analysis of Plethysmograms and the Effect of Communication on Dementia in Elderly Individuals
      1. ABSTRACT
      2. INTRODUCTION
      3. MATHEMATICAL MODEL
      4. VERIFICATION FROM ANESTHETIZING EXPERIMENT
      5. STUDIES OF ELDERLY SUBJECTS WITH DIFFERENT COMMUNICATION SKILLS
      6. MEASUREMENT OF THE EFFECT OF COMMUNICATION-DEPENDENT REHABILITATION
      7. CONCLUSION
    12. Chapter 26: Diffusion Tensor Imaging for Dementia
      1. ABSTRACT
      2. I. INTRODUCTION
      3. II. BASICS OF DTI AND TRACTOGRAPHY
      4. III. LIMITATIONS OF TRACTOGRAPHY
      5. IV. CLINICAL APPLICATION
      6. V. CONCLUSION
    13. Chapter 27: The Important Role of Lipids in Cognitive Impairment
      1. ABSTRACT
      2. I. INTRODUCTION
      3. II. MATERIALS AND METHODS
      4. III. RESULTS
      5. IV. DISCUSSION
      6. V. CONCLUSION
    14. Chapter 28: Noninvasive Detection of Misfolded Proteins in the Brain Using [11C]BF-227 PET
      1. ABSTRACT
      2. INTRODUCTION
      3. EXPERIMENT
      4. RESULTS
      5. DISCUSSION
    15. Chapter 29: Quantitative Analysis of Amyloid β Deposition in Patients with Alzheimer’s Disease Using Positron Emission Tomography
      1. ABSTRACT
      2. INTRODUCTION
      3. MATERIALS AND METHODS
      4. RESULTS
      5. DISCUSSION
    16. Chapter 30: Neuroimaging in Alzheimer’s Disease
      1. ABSTRACT
      2. I. INTRODUCTION
      3. II. PET AND SPECT IMAGING
      4. III. NEW TRACERS FOR AD DIAGNOSIS
      5. IV. LEWY BODY DISEASE AND PARKINSON’S DISEASE
      6. V. ALZHEIMER DISEASE NEUROIMAGING INITIATIVE
    17. Chapter 31: In Vivo Optical Imaging of Brain and its Application in Alzheimer's Disease
      1. ABSTRACT
      2. I. TWO-PHOTON LASER SCANNING MICROSCOPY
      3. II. INTRINSIC OPTICAL SIGNAL IMAGING
      4. III. VOLTAGE-SENSITIVE DYE IMAGING
      5. FUTURE DIRECTIONS
  8. Section 3:
    1. Chapter 32: The Relationship between Knee Extension Strength and Activities of Daily Living in Patients with Dementia
      1. ABSTRACT
      2. INTRODUCTION
      3. RELIABILITY OF KNEE EXTENSION STRENGTH MEASUREMENTS OBTAINED IN PATIENTS WITH DEMENTIA
      4. RESULTS
      5. RELATIONSHIP BETWEEN KNEE EXTENSION STRENGTH AND LOWER EXTREMITY FUNCTION IN PATIENTS WITH DEMENTIA
      6. RESULTS
      7. DISCUSSION
    2. Chapter 33: Music Therapy for Dementia Patients
      1. ABSTRACT
      2. INTRODUCTION
      3. THEORY
      4. RESULTS
      5. DISCUSSION
    3. Chapter 34: Development of Neurorehabilitation Techniques Using Transcranial Magnetic Stimulation with Voluntary Muscle Contraction
      1. ABSTRACT
      2. INTRODUCTION
      3. EXPERIMENT
      4. RESULTS
      5. CONCLUSION
    4. Chapter 35: Development of Tactile Display Devices Using fMRI under High Magnetic Fields
      1. ABSTRACT
      2. INTRODUCTION
      3. TACTILE SENSE
      4. TACTILE DISPLAY DEVICES
      5. EXPERIMENT AND RESULTS
      6. DISCUSSION AND CONCLUSION
    5. Chapter 36: Development of a Bilateral Assistance and Coordination Rehabilitation Training System
      1. ABSTRACT
      2. INTRODUCTION
      3. RESEARCH OBJECTIVES
      4. BILATERAL ASSISTANCE AND COORDINATION REHABILITATION SYSTEM
      5. RESULTS
      6. CONCLUSION
    6. Chapter 37: The Use of Mesh Glove Neurostimulation for Motor Recovery in Chronic Stroke
      1. ABSTRACT
      2. I. INTRODUCTION
      3. II. MATERIALS AND METHODS
      4. III. RESULTS
      5. IV. DISCUSSION
      6. V. CONCLUSION
    7. Chapter 38: Novel Rehabilitation Devices for Hand Movement Disorders
      1. ABSTRACT
      2. INTRODUCTION
      3. HAND REHABILITATION DEVICES
      4. DEVELOPMENT OF A HOME REHABILITATION DEVICE
      5. CONCLUSION AND FUTURE WORK
    8. Chapter 39: A Novel Length Display Device for Cognitive Experiments and Rehabilitation
      1. ABSTRACT
      2. INTRODUCTION
      3. 2DOF LENGTH DISPLAY DEVICE
      4. 4DOF LENGTH DISPLAY DEVICE
      5. REHABILITATION
      6. CONCLUSION
    9. Chapter 40: A Log-linearized Viscoelastic Model for Measuring Changes in Vascular Impedance
      1. ABSTRACT
      2. INTRODUCTION
      3. LOG-LINEARIZED ARTERIAL VISCOELASTIC MODEL
      4. METHOD
      5. RESULTS
      6. DISCUSSION
      7. CONCLUSION
    10. Chapter 41: Surface EMG and Upper-Limb Rehabilitation
      1. ABSTRACT
      2. INTRODUCTION
      3. EXPERIMENT
      4. RESULTS AND DISCUSSION
    11. Chapter 42: A Method for Eliciting the Support Needs from People with Early-Stage Dementia for Maintaining Social Living
      1. ABSTRACT
      2. INTRODUCTION
      3. A NEW METHOD OF IDENTIFYING SUPPORT NEEDS
      4. DISCUSSION
      5. CONCLUSION
    12. Chapter 43: The Coimagination Method and its Evaluation via the Conversation Interactivity Measuring Method
      1. ABSTRACT
      2. INTRODUCTION
      3. COIMAGINATION METHOD
      4. EVALUATION OF THE COIMAGINATION METHOD VIA CIMM
      5. DISCUSSION
      6. CONCLUSION
    13. Chapter 44: An International Investigation of Driver’s Licenses for Dementia Patients with Considerations of Their Social Circumstances
      1. ABSTRACT
      2. INTRODUCTION
      3. EXPERIMENT
      4. DISCUSSION
  9. Compilation of References
  10. About the Contributors