Replication can be across sites or at the same site. If you choose to replicate the VMs that you plan to protect, to a datastore at the same site, then you can use vSphere Replication to achieve the same.
Configuring replication requires the availability of a replication server (VRS) at the target site, be it local or remote. Since you have already deployed a vSphere Replication Appliance that includes both the VRMS and VRS components, there is no need for an additional step to get the replication working at the local site.
The following procedure will guide you through the steps required to configure replication for a VM to a local or remote vCenter site: