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Developments in Tissue Engineered and Regenerative Medicine Products by J Ludlow, J Basu

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5

Neo-Urinary Conduit™

Abstract

The Neo-Urinary Conduit™ is a tubular neo-organ composed of native-like urinary tissue mediating efflux of urine from the body in patients requiring urinary diversion. Its development from concept to clinical trials is presented here as an illustrative example highlighting issues common to bioprocess development of novel TE/RM products based on cell/biomaterial composite constructs.

Keywords

scaffold

smooth muscle cell

regeneration

tissue engineering

urinary conduit

urinary diversion

biomaterial

neo-organ

5.1 Introduction

During efforts to transition the Neo-Bladder Replacement™ (Chapter 4) through the clinical trials process, alternative strategies for mediating efflux of urine from the body were considered. ...

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