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Developments in Tissue Engineered and Regenerative Medicine Products by J Ludlow, J Basu

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3

Biomaterials for TE/RM products

Abstract

Biomaterials may be required to support the cellular active biological ingredient within the context of a TE/RM product. In this chapter, we briefly review the principal classes of natural and synthetic biomaterials commonly used within the TE/RM industry. We illustrate the selection criteria for identification of appropriate biomaterial candidates for TE/RM product application using ‘real world’ examples from Tengion’s ongoing development of Neo-Kidney Augment™ and Neo-Bladder Augment™ and Neo-Gastrointestinal tract (Neo-GI™) regeneration programs.

Keywords

biomaterials

extracellular matrix

decell/recell

hydrogel

chronic kidney disease

gelatin

poly-caprolactone

poly-glycolic acid

poly-lactic-co ...

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