Chapter 8. Repeated Measures Analysis

  • 8.1 Introduction 125

  • 8.2 Synopsis 125

  • 8.3 Examples 129

  • 8.4 Details & Notes 160

8.1 Introduction

Repeated measures refer to multiple measurements taken from the same experimental unit, such as serial evaluations over time on the same patient. Special attention is given to these types of measurements because they cannot be considered independent. In particular, the analysis must make provisions for the correlation structure.

Most clinical studies require outpatients to return to the clinic for multiple visits during the trial with response measurements made at each. This is the most common example of a repeated measures experiment in clinical trials. The data generated are sometimes referred to as 'longitudinal' data. ...

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