THE SAMPLES

What population(s) was/were sampled from? Were these the same populations to which the report(s) conclusions were applied?

For example, studies of the possibilities of whiplash resulting from low-speed rear-end collisions would only be relevant to specific court cases if the subjects of the studies were of the same age, physical condition, and history of prior injuries as the subjects in the court cases, and if the speeds of impact and the masses and protective ability of the vehicles involved were the same in both the studies and the court cases.

How large was the sample? This most basic piece of information is lacking from the report by Okano et al. [1993]. Was the sample random, stratified, or clustered? What was the survey unit? Was the sample representative? Can you verify this from the information provided in the report?

For example, when several groups are to be compared, baseline information for each group should be provided. A careful reading of Fujita et al. [2000] reveals that the baseline values (age and bone density) of the various groups were quite different, casting doubt on the reported findings.

How was the sample size determined? Was the anticipated power stated explicitly? Without knowledge of the sample size and the anticipated power of the test, we will be unable to determine what interpretation, if any, ought be given a failure to detect a statistically significant effect.

What method of allocation to subgroup was used? What type of blinding was ...

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