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Coatings for Biomedical Applications

Book Description

The biomaterials sector is rapidly expanding and significant advances have been made in the technology of biomedical coatings and materials, which provide a means to improve the wear of joints, change the biological interaction between implant and host and combine the properties of various materials to improve device performance. Coatings for biomedical applications provides an extensive review of coating types and surface modifications for biomedical applications.

The first part of the book explores a range of coating types and their biomedical applications. Chapters look at hydrophilic, mineral and pyrolytic carbon coatings in and ex vivo orthopaedic applications and finally at surface modification and preparation techniques. Part two presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices.

With its clear structure and comprehensive review of research, Coatings for biomedical applications is a valuable resource to researchers, scientists and engineers in the biomedical industry. It will also benefit anyone studying or working within the biomedical sector, particularly those specialising in biomedical coatings.

  • Provides an extensive review of coating types and surface modifications for biomedical applications
  • Chapters look at hydrophilic coatings for biomedical applications in and ex vivo, mineral coatings for orthopaedic applications, pyrolytic carbon coating and other commonly-used biomedical coatings
  • Presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices

Table of Contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Contributor contact details
  6. Preface
  7. Part I: Coating types and applications
    1. Chapter 1: Hydrophilic coatings for biomedical applications in and ex vivo
      1. Abstract:
      2. 1.1 Introduction
      3. 1.2 Examples of hydrophilic coatings
      4. 1.3 Applications for hydrophilic coatings in the clinical environment (ex vivo)
      5. 1.4 Applications for hydrophilic coatings in the clinical environment (in vivo)
      6. 1.5 Conclusions and future trends
      7. 1.6 Sources of further information
      8. 1.8 Appendix: list of suppliers of hydrophilic coatings for biomedical devices
    2. Chapter 2: Mineral coatings for orthopaedic applications
      1. Abstract:
      2. 2.1 Introduction
      3. 2.2 Important characteristics of mineral coatings
      4. 2.3 Coating methods
      5. 2.4 Clinical studies
      6. 2.5 Future trends
      7. 2.6 Sources of further information
    3. Chapter 3: Other commonly used biomedical coatings: pyrolytic carbon coatings
      1. Abstract:
      2. 3.1 Introduction
      3. 3.2 Carbon solid materials
      4. 3.3 Carbon film coatings
      5. 3.4 Pyrolytic carbon coatings
      6. 3.5 Conclusion
    4. Chapter 4: Electrochemical surface modifications of titanium and titanium alloys for biomedical applications
      1. Abstract:
      2. 4.1 Introduction
      3. 4.2 Electrochemical treatments
      4. 4.3 Future trends in chemical and electrochemical treatments
      5. 4.4 Conclusions
      6. 4.5 Acknowledgements
      7. 4.7 Appendix: list of abbreviations
    5. Chapter 5: Surface preparation techniques for biomedical applications
      1. Abstract:
      2. 5.1 Introduction
      3. 5.2 Sonication
      4. 5.3 Mechanical polishing
      5. 5.4 Electropolishing
      6. 5.5 Chemical etching
      7. 5.6 Plasma treatment
      8. 5.7 Priming
      9. 5.8 Future trends
      10. 5.9 Sources of further information
    6. Chapter 6: Characterisation of biomedical coatings
      1. Abstract:
      2. 6.1 Introduction
      3. 6.2 Surfaces, concepts and techniques
      4. 6.3 Contact angle
      5. 6.4 Analysis of adhesion
      6. 6.5 Scanning probe microscopy
      7. 6.6 Confocal microscopy
      8. 6.7 Scanning electron microscopy and transmission electron microscopy
      9. 6.8 Spectroscopic methods
      10. 6.9 Optical detection methods
      11. 6.10 Neutron reflectivity
      12. 6.11 Other techniques
      13. 6.12 Future trends
      14. 6.13 Sources of further information
  8. Part II: Case studies
    1. Chapter 7: Coatings for cardiovascular devices: coronary stents
      1. Abstract:
      2. 7.1 Introduction: heart disease its treatments
      3. 7.2 Artery structure and mechanism of restenosis
      4. 7.3 Commercial drug-eluting stent (DES) systems
      5. 7.4 Increased use of DES and concerns surrounding stent thrombosis
      6. 7.5 Second generation DES systems
      7. 7.6 Other approaches and future trends
      8. 7.7 Conclusions
    2. Chapter 8: Coatings for cardiovascular devices: extracorporeal circuits
      1. Abstract:
      2. 8.1 Background of coatings for extracorporeal circulation
      3. 8.2 Coatings for left-heart bypass
      4. 8.3 Coatings for cardiopulmonary bypass
      5. 8.4 Coatings for mechanical circulatory support
      6. 8.5 Coatings for other devices in cardiothoracic surgery
      7. 8.6 Conclusions
    3. Chapter 9: Surface coatings for ventricular assist devices
      1. Abstract:
      2. 9.1 Introduction
      3. 9.2 Ventricular assist devices (VADs)
      4. 9.3 Hemocompatible surface coatings for VADs
      5. 9.4 Future trends
      6. 9.5 Conclusions
    4. Chapter 10: Orthopaedic coatings
      1. Abstract:
      2. 10.1 History of joint replacement
      3. 10.2 Development of joint replacement prostheses
      4. 10.3 Development of cementless fixation
      5. 10.4 Thermal spray coating techniques
      6. 10.5 Coating characteristics
      7. 10.6 Alternative coating methods
      8. 10.7 Clinical experience
      9. 10.8 Acknowledgements
    5. Chapter 11: Surface coatings in urology
      1. Abstract:
      2. 11.1 Introduction
      3. 11.2 Indwelling bladder catheters
      4. 11.3 Biofilm formation on implanted urological devices
      5. 11.4 Challenges in controlling catheter-associated urinary tract infection
      6. 11.5 Developments in antimicrobial catheters
      7. 11.6 The catheter encrustation problem
      8. 11.7 Ureteric stents
      9. 11.8 Conclusions
    6. Chapter 12: Ophthalmic coatings
      1. Abstract:
      2. 12.1 Introduction
      3. 12.2 Contact lenses
      4. 12.3 Artificial cornea
      5. 12.4 Intraocular lenses
      6. 12.5 Other ophthalmic devices
      7. 12.6 Conclusions
  9. Index