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CMOS Biomicrosystems: Where Electronics Meet Biology

Book Description

The book will address the-state-of-the-art in integrated Bio-Microsystems that integrate microelectronics with fluidics, photonics, and mechanics. New exciting opportunities in emerging applications that will take system performance beyond offered by traditional CMOS based circuits are discussed in detail. The book is a must for anyone serious about microelectronics integration possibilities for future technologies.

The book is written by top notch international experts in industry and academia. The intended audience is practicing engineers with electronics background that want to learn about integrated microsystems. The book will be also used as a recommended reading and supplementary material in graduate course curriculum.

Table of Contents

  1. Cover
  2. Title page
  3. Copyright page
  4. PREFACE
  5. CONTRIBUTORS
  6. PART I: HUMAN BODY MONITORING
    1. 1 INTERFACING BIOLOGY AND CIRCUITS: QUANTIFICATION AND PERFORMANCE METRICS
      1. 1.1 INTRODUCTION
      2. 1.2 THE SIGNAL PROCESSING AIM
      3. 1.3 REPRESENTATIVE TESTING
      4. 1.4 PERFORMANCE METRICS
      5. 1.5 STATISTICAL VALIDATION
      6. 1.6 CONCLUSIONS
    2. 2 FULLY INTEGRATED SYSTEMS FOR NEURAL SIGNAL RECORDING: TECHNOLOGY PERSPECTIVE AND LOW-NOISE FRONT-END DESIGN
      1. 2.1 INTRODUCTION
      2. 2.2 NEURAL SIGNALS AND FRONT-END REQUIREMENTS
      3. 2.3 SYSTEM ARCHITECTURE AND POWER BUDGET PARTITIONING
      4. 2.4 PREAMPLIFIER AND FILTER
      5. 2.5 SYSTEM INTEGRATION AND RESULTS
      6. 2.6 REFINEMENTS OF AMPLIFIER DESIGN
      7. 2.7 CONCLUSIONS
    3. 3 VLSI IMPLEMENTATION OF WIRELESS NEURAL RECORDING MICROSYSTEM FOR NEUROMUSCULAR STIMULATION
      1. 3.1 REVIEW OF THE RECORDING MICROSYSTEM
      2. 3.2 WIRELESS POWER AND DATA TRANSMISSION MICROSTIMULATOR SYSTEM
      3. 3.3 VERY LARGE-SCALE INTEGRATED CIRCUITS IN THE RECORDING MICROSYSTEM
      4. 3.4 CONCLUSION
    4. 4 HEALTH-CARE DEVICES USING RADIO FREQUENCY TECHNOLOGY
      1. 4.1 INTRODUCTION
      2. 4.2 REMOTE DETECTION OF HUMAN VITAL SIGNS
      3. 4.3 HEALTH-CARE SENSOR USING RADIO FREQUENCY TECHNOLOGY
      4. 4.4 MEASUREMENTS
      5. 4.5 CONCLUSION
      6. ACKNOWLEDGMENTS
    5. 5 DESIGN CONSIDERATIONS OF LOW-POWER DIGITAL INTEGRATED SYSTEMS FOR IMPLANTABLE MEDICAL APPLICATIONS
      1. 5.1 INTRODUCTION
      2. 5.2 GENERAL MODEL OF IMPLANTABLE MEDICAL ELECTRONIC DEVICES
      3. 5.3 DESIGN CONSIDERATIONS OF LOW-POWER DIGITAL INTEGRATED CIRCUIT DESIGN INSIDE AN IMPLANT UNIT
      4. 5.4 A DESIGN CASE: LOW-POWER DIGITAL INTEGRATED CIRCUIT DESIGN FOR WIRELESS CAPSULE ENDOSCOPY
      5. 5.5 CONCLUSION
  7. PART II: BIOSENSORS AND CIRCUITS
    1. 6 AFFINITY-BASED BIOSENSORS: STOCHASTIC MODELING AND FIGURES OF MERIT
      1. 6.1 MODELING BIOSENSORS: INTRODUCTION
      2. 6.2 BIOSENSOR MODEL: DETERMINISTIC AND STOCHASTIC
      3. 6.3 SIGNAL-TO-NOISE RATIO AND NOISE FIGURE DEFINITIONS
      4. 6.4 TRANSIENT SIGNAL-TO-NOISE RATIO ANALYIS
      5. 6.5 SIMULATIONS
      6. 6.6 CONCLUSION
    2. 7 FABRICATION EXAMPLES BASED ON STANDARD CMOS AND MEMS PROCESSES
      1. 7.1 THE NEED FOR INFRASTRUCTURES
      2. 7.2 INTEGRATED CIRCUIT MANUFACTURING AT CMP
      3. 7.3 MICRO-ELECTROMECHANICAL SYSTEMS MANUFACTURING AT CMP
      4. 7.4 OTHER MAJOR INFRASTRUCTURES
      5. 7.5 ICs AND MICRO-ELECTROMECHANICAL SYSTEMS FOR BIOMEDICAL APPLICATIONS
      6. 7.6 CONCLUSIONS
    3. 8 CMOS CAPACITIVE BIOINTERFACES FOR LAB-ON-CHIP APPLICATIONS
      1. 8.1 INTRODUCTION
      2. 8.2 ON-CHIP SENSING ELECTRODES
      3. 8.3 CAPACITIVE BIOCHEMICAL METHODS
      4. 8.4 CAPACITIVE INTERFACE CIRCUITS
      5. 8.5 MICROFLUIDIC PACKAGING
      6. 8.6 CONCLUSION
    4. 9 LENSFREE IMAGING CYTOMETRY AND DIAGNOSTICS FOR POINT-OF-CARE AND TELEMEDICINE APPLICATIONS
      1. 9.1 INTRODUCTION
      2. 9.2 CLINICAL NEED FOR CYTOMETRY AND ITS SIGNIFICANCE FOR BIOMEDICAL DIAGNOSTICS
      3. 9.3 MODERN CYTOMETRY TECHNOLOGIES
      4. 9.4 AN EMERGING LENSLESS OPTICAL TECHNOLOGY FOR HIGH-THROUGHPUT ON-CHIP CYTOMETRY AND DIAGNOSTICS: LUCAS
      5. 9.5 CONCLUSION
    5. 10 ADVANCED TECHNOLOGIES FOR REAL-TIME MONITORING AND CONTROL IN BIOMICROFLUIDICS
      1. 10.1 INTRODUCTION
      2. 10.2 BIOMICROFLUIDICS SYSTEMS AND RELATED ISSUES
      3. 10.3 POINTWISE FLOW MONITORING
      4. 10.4 CELLULAR NONLINEAR NETWORKS-BASED FULL-FIELD MONITORING
      5. 10.5 CELLULAR NONLINEAR NETWORKS APPLICATIONS IN BIOMICROFLUIDICS
      6. 10.6 DISCUSSION ON FUTURE TRENDS
      7. ACKNOWLEDGMENTS
    6. 11 MONITORING OF STEM CELL CULTURE PROCESS USING ELECTROCHEMICAL BIOSENSORS
      1. 11.1 INTRODUCTION
      2. 11.2 BUILDING A MEASUREMENT SYSTEM
      3. 11.3 STEM CELL CULTURE PROCESS MONITORING
      4. 11.4 SUMMARY
  8. PART III: EMERGING TECHNOLOGIES
    1. 12 BUILDING INTERFACES TO DEVELOPING CELLS AND ORGANISMS: FROM CYBORG BEETLES TO SYNTHETIC BIOLOGY
      1. 12.1 INTRODUCTION
      2. 12.2 EXAMPLE INTERFACES
      3. 12.3 CONCLUSIONS
    2. 13 TECHNOLOGIES FOR ARRAYED SINGLE-CELL BIOLOGY
      1. 13.1 THE IMPORTANCE OF STUDYING SINGLE CELLS
      2. 13.2 ELECTRONIC DETECTION OF MOLECULES IN THE NANOSCALE
      3. 13.3 SINGLE-CELL RESPIRATION MEASUREMENTS
      4. 13.4 OXYGEN DETECTION
      5. 13.5 OVERVIEW OF THE MINIATURE CELL INCUBATOR PLATFORM
      6. 13.6 OXYGEN CONSUMPTION RATE MEASUREMENTS USING A SINGLE-CELL SELF-ASSEMBLY METHOD
      7. 13.7 CONCLUSION
      8. ACKNOWLEDGMENTS
    3. 14 APPLICATION OF BACTERIAL FLAGELLAR MOTORS IN MICROFLUIDIC SYSTEMS
      1. 14.1 INTRODUCTION
      2. 14.2 FLAGELLAR MOTOR MICROPUMP
      3. 14.3 EXPERIMENTAL STUDIES
      4. 14.4 CONCLUDING REMARKS
      5. ACKNOWLEDGMENTS
    4. 15 GENE INJECTION AND MANIPULATION USING CMOS-BASED TECHNOLOGIES
      1. 15.1 INTRODUCTION
      2. 15.2 PHYSICAL STRATEGIES FOR GENE INJECTION
      3. 15.3 CHALLENGES IN BIOCHIP–CMOS INTEGRATION
      4. 15.4 CONCLUSIONS AND FUTURE OUTLOOK
    5. 16 LOW-COST DIAGNOSTICS: RF DESIGNER'S APPROACH
      1. 16.1 INTRODUCTION
      2. 16.2 REVIEW OF NUCLEAR MAGNETIC RESONANCE
      3. 16.3 CMOS RADIO FREQUENCY TRANSCEIVER INTEGRATED CIRCUIT DESIGN: CHALLENGES
      4. 16.4 CMOS RADIO FREQUENCY TRANSCEIVER INTEGRATED CIRCUIT DESIGN: ARCHITECTURE
      5. 16.5 CMOS RADIO FREQUENCY TRANSCEIVER INTEGRATED CIRCUIT DESIGN: FRONT-END DESIGN
      6. 16.6 CMOS RADIO FREQUENCY TRANSCEIVER INTEGRATED CIRCUIT DESIGN: OTHER CIRCUIT CONSIDERATIONS
      7. 16.7 EXPERIMENTS
      8. 16.8 CONCLUSION
      9. ACKNOWLEDGMENTS
  9. INDEX