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Characterization of Biomaterials by T Arinzeh, P Tolias, W. Hammond, M Jaffe

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6

Studying molecular-scale protein–surface interactions in biomaterials

Abstract:

Protein interactions with implant surface are an integral part of a series of events that could determine the outcome of the implant devices. Atomic force microscopy (AFM), when operates under fluid conditions, allows proteins to maintain their natural functionality. AFM provides important information regarding the interfacial properties of fibrinogen, such as molecular conformations in three dimensions, and corresponding functionalities, temporal and temperature-dependent adsorption profile and adhesion strength. It has been demonstrated that the structure–function relationship of fibrinogen is a function of the physio-chemical properties of the underlying substrates. ...

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