17.3. Mantel-Cox Test

You are often interested in comparing survival curves to determine which treatment had the more favorable outcome. Mantel (1966) and later Cox (1972) suggested an extension of the Mantel-Haenszel methodology that applies to survival data. You restructure the usual frequency table format of the data to a set of 2 × 2 tables, each with a life table format, and perform the Mantel-Haenszel computations on that set of tables.

The tables are generated by regarding treatment as the row variable, the numbers recurred and not recurred as the column variable, and the intervals as the strata. You are thus proceeding as though the time interval results are uncorrelated; methodological results for survival analysis establish that you ...

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