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Categorical Data Analysis Using The SAS® System, 2nd Edition by Gary G. Koch, Charles S. Davis, Maura E. Stokes

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10.3. Clinical Trials Study Analysis

Researchers studying the effect of a new treatment on a skin condition collected information from 79 clinics. In each clinic, one patient received the treatment, and another patient received a placebo. Variables collected included age, sex, and an initial grade for the skin condition, which ranged from 1 to 4 for mild to severe. The response variable was whether the skin condition improved. Using conditional logistic regression is suitable for the analysis of such data, and, in this example, both the LOGISTIC and PHREG procedures are implemented. The PROC LOGISTIC analysis demonstrates that the case of paired observations can be handled with the computations of the unconditional logistic regression on the ...

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