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Biosensors for Medical Applications

Book Description

Biomedical sensors are an essential tool in the detection and monitoring of a wide range of medical conditions from cancer to Parkinson’s disease. Biosensors for medical applications provides a comprehensive review of established, cutting edge and future trends in biomedical sensors and their applications.

Part one focuses on key principles and transduction approaches, reviewing electrochemical, piezoelectric and nano-sized biosensors. Impedence interrogated affinity biosensors for medical applications and practical applications of enzyme biosensors are explored, before part two goes on to review specific medical applications. Biosensors for DNA and RNA detection and characterization, disease biomarker detection, and the use of affibodies as an alternative to antibodies in cancer marker biosensors are investigated, along with biosensors for drug testing and discovery, non-invasive measurements, and wearable biosensors for medical applications.

With its distinguished editor and international team of expert contributors, Biosensors for medical applications is an essential guide for all those involved in the research, design, production and use of medical biosensors.

  • Provides a comprehensive review of established, cutting edge and future trends in biomedical sensors and their applications
  • Examines key principles and transduction approaches, reviewing electrochemical, piezoelectric and nano-sized biosensors
  • Reviews biosensors for DNA and RNA detection and characterisation, disease biomarker detection, and the use of affibodies as an alternative to antibodies in cancer marker biosensors

Table of Contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Contributor contact details
  6. Woodhead Publishing Series in Biomaterials
  7. Introduction to biosensors
  8. Part I: Principles and transduction approaches
    1. Chapter 1: Electrochemical biosensors for medical applications
      1. Abstract:
      2. 1.1 Introduction to electrochemical sensors
      3. 1.2 Electrochemical biosensing applications
      4. 1.3 Label-free approaches to electrochemical sensors
      5. 1.4 Conclusion and future trends
    2. Chapter 2: Piezoelectric biosensors for medical applications
      1. Abstract:
      2. 2.1 Introduction
      3. 2.2 Piezoelectric immunosensors
      4. 2.3 Piezoelectric genosensors
      5. 2.4 Piezoelectric biosensors with bio-mimetic receptors
      6. 2.5 Conclusions and future trends
    3. Chapter 3: Nano-sized biosensors for medical applications
      1. Abstract:
      2. 3.1 Introduction
      3. 3.2 Sensing modalities
      4. 3.3 Nanomaterial properties
      5. 3.4 Biosensors on the nanoscale
      6. 3.5 Conclusions
    4. Chapter 4: Impedance interrogated affinity biosensors for medical applications: novel targets and mechanistic studies
      1. Abstract:
      2. 4.1 Small molecule binding
      3. 4.2 Supramolecular structures
      4. 4.3 Electrochemical biosensor for clinical diagnostics
      5. 4.4 Challenges of carbohydrate sensing
      6. 4.5 Bioreceptors for carbohydrate sensing
      7. 4.6 Enzymes that act on carbohydrates
      8. 4.7 Impedimetric glucose biosensors
      9. 4.8 Impedimetric bacterial and viral immunosensors
      10. 4.9 Impedance and pathogens
      11. 4.10 Bioreceptors used in impedimetric pathogenic biosensor construction
      12. 4.11 Detection of exposure to infection
      13. 4.12 Conclusion
    5. Chapter 5: Practical applications and protocols for enzyme biosensors
      1. Abstract:
      2. 5.1 Introduction
      3. 5.2 Methods and approaches for using biosensors
      4. 5.3 Protocols for enzyme biosensors
      5. Method
      6. 5.4 Problems arising from the construction and use of biosensors
  9. Part II: Applications of medical biosensors
    1. Chapter 6: Biosensors for DNA and RNA detection and characterization
      1. Abstract:
      2. 6.1 Introduction to nucleic acids and base pairing
      3. 6.2 Principles of DNA/RNA sensing
      4. 6.3 Electrochemical DNA sensing
      5. 6.4 Optical DNA sensing
      6. 6.5 Quartz crystal microbalance and surface acoustic wave sensors
      7. 6.6 Microcantilever oligonucleotide sensors
      8. 6.7 Conclusions
    2. Chapter 7: Biosensors for disease biomarker detection
      1. Abstract:
      2. 7.1 Introduction
      3. 7.2 Disease biomarkers
      4. 7.3 Established technologies for disease biomarker detection
      5. 7.4 Proteins at surfaces
      6. 7.5 Emerging technologies for disease biomarker detection
      7. 7.6 Future trends
      8. 7.7 Sources of further information and advice
    3. Chapter 8: Affibodies as an alternative to antibodies in biosensors for cancer markers
      1. Abstract:
      2. 8.1 Introduction: cancer
      3. 8.2 Breast cancer
      4. 8.3 Human epidermal growth factor receptor 2 (HER2)
      5. 8.4 The immunoassay
      6. 8.5 Biosensors
      7. 8.6 Problems with antibodies
      8. 8.7 Affibodies
    4. Chapter 9: Biosensors for drug testing and discovery
      1. Abstract:
      2. 9.1 Introduction
      3. 9.2 Types of biosensor
      4. 9.3 Conclusion
      5. 9.4 Acknowledgements
    5. Chapter 10: Biosensors for non-invasive measurements
      1. Abstract:
      2. 10.1 Introduction
      3. 10.2 Biosensors for the detection of alcohol and lactate
      4. 10.3 Detection using electrochemical and amperometric biosensors
      5. 10.4 Detection using optical biosensors
      6. 10.5 Conclusions
    6. Chapter 11: Wearable biosensors for medical applications
      1. Abstract:
      2. 11.1 Introduction
      3. 11.2 Background
      4. 11.3 Considerations and requirements for wearable sensors
      5. 11.4 Types of wearable sensors
      6. 11.5 Temperature sensors
      7. 11.6 Mechanical sensors
      8. 11.7 Electrical sensors
      9. 11.8 Biological and chemical sensing
      10. 11.9 Clinical applications
      11. 11.10 Future trends
      12. 11.11 Sources of further information and advice
  10. Index