This recipe will not require any pre-downloaded data, but as we are using the web APIs, internet access will be needed. The amount of data being transferred will be limited.
We will also make use of the requests library to access Ensembl. The request API is an easy-to-use wrapper for web requests. Of course, you can use the standard Python libraries, but these are much more cumbersome.
As usual, you can find this content in the Chapter03/Orthology.ipynb Notebook file.