So, how can we infer the quality of calls using Mendelian inheritance rules? Let's look at expectations for different genotypical configurations of the parents:
- For a certain potential bi-allelic SNP, if the mother is AA and the father is also AA, then all offspring will be AA.
- If the mother is AA and the father TT, then all offspring will have to be heterozygous (AT). They always get an A from the mother and they always get a T from the father.
- If the mother is AA and the father is AT, then offspring can be either AA or AT. They always get the A from the mother, but they can get either an A or a T from the father.
- If the both the mother and the father are heterozygous (AT), then the ...
