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Biodesign by Paul Yock, Josh Makower, Stefanos Zenios

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2.1 Disease State Fundamentals

Introduction
In the excitement of having identified one or more compelling needs, an innovator’s instinct may be to quickly jump ahead and begin inventing. However, establishing a detailed knowledge of the relevant disease state, with a particular focus on its mechanism of action, is fundamental to validating any need and understanding how it can best be addressed. Disciplined disease state research is an essential part of the biodesign innovation process and an invaluable activity for clinician and non-clinician innovators alike.
Understanding disease state fundamentals involves researching the anatomy and physiology, pathophysiology, symptoms, outcomes, epidemiology, and economic impact of a disease. This information ...

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