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Aggression by Jose da Silveira, Malcolm Lader, Alyson Bond

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CHAPTER SEVEN

The effects of alprazolam on behavioural aggression

INTRODUCTION

These studies were a logical extension of those presented in Chapters 5 and 6. Increased aggressive responding on laboratory tasks has been found in normal volunteers after being given chlordiazepoxide (Salzman et al., 1974), diazepam (Gantner & Taylor, 1988; Wilkinson, 1985) and lorazepam (Chapter 6). Alprazolam is a newer triazolobenzodiazepine of high potency, its anxiolytic dose being 1.5 to 3mg/day. It also has anti-panic effects at higher doses, raising the possibility of enhanced ceiling efficacy (e.g. Ballenger et al., 1988). However, it has been reported to increase verbal hostility and behavioural dyscontrol in a proportion of patients (Rosenbaum et al., ...

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