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Aggression by Jose da Silveira, Malcolm Lader, Alyson Bond

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CHAPTER SIX

The effects of benzodiazepines on behavioural aggression

INTRODUCTION

Benzodiazepines have been in clinical use since the early 1960s. Initially they were claimed to have anti-aggressive as well as anxiolytic properties, although the animal literature has been equivocal (Rodgers & Waters, 1985), differing according to species and test. Reports of rage attacks in humans occurred early on (e.g. Boyle & Tobin, 1961) and were labelled paradoxical reactions as they tended to occur in isolated instances and usually at high doses (Bond & Lader, 1979). Reports have continued with the newer benzodiazepines (Rosenbaum et al., 1984). Laboratory studies have suggested that chlordiazepoxide and diazepam but not oxazepam increase hostility or aggressive ...

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