Microsoft Excel can be a powerful tool for statistical analysis. This chapter discusses a very small subset of these tools. The main focus is on the treatment of variability associated with data measurements. Some of the functions introduced are: AVERAGE, DEVSQ, FREQUENCY, STDEV, TDIST, TINV, and TTEST. This chapter discusses descriptive statistics, frequency distribution, and confidence limits. It compares the mean from two sets of measurements made on a set of samples. Set A is the measurement using one technique, while set B was obtained from another.