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3D Bioprinting

Book Description

3D Bioprinting: Fundamentals, Principles and Applications provides the latest information on the fundamentals, principles, physics, and applications of 3D bioprinting. It contains descriptions of the various bioprinting processes and technologies used in additive biomanufacturing of tissue constructs, tissues, and organs using living cells. The increasing availability and decreasing costs of 3D printing technologies are driving its use to meet medical needs, and this book provides an overview of these technologies and their integration. Each chapter discusses current limitations on the relevant technology, giving future perspectives.

Professor Ozbolat has pulled together expertise from the fields of bioprinting, tissue engineering, tissue fabrication, and 3D printing in his inclusive table of contents. Topics covered include raw materials, processes, machine technology, products, applications, and limitations. The information in this book will help bioengineers, tissue and manufacturing engineers, and medical doctors understand the features of each bioprinting process, as well as bioink and bioprinter types. In addition, the book presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics.



  • Describes all aspects of the bioprinting process, from bioink processing through design for bioprinting, bioprinting techniques, bioprinter technologies, organ printing, applications, and future trends
  • Provides a detailed description of each bioprinting technique with an in-depth understanding of its process modeling, underlying physics and characteristics, suitable bioink and cell types printed, and major accomplishments achieved thus far
  • Explains organ printing technology in detail with a step-by-step roadmap for the 3D bioprinting of organs from isolating stem cells to the post-transplantation of organs
  • Presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics

Table of Contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Dedication
  5. Copyright
  6. About the Author
  7. Preface
  8. Acknowledgments
  9. 1. Introduction
    1. 1.1. Tissue Engineering
    2. 1.2. Three-Dimensional Printing in Tissue Engineering
    3. 1.3. Three-Dimensional Bioprinting
    4. 1.4. The Organization of the Book
    5. 1.5. Summary
  10. 2. Design for Bioprinting
    1. 2.1. Introduction
    2. 2.2. Design Requirements for Three-Dimensional Bioprinting
    3. 2.3. Medical Imaging
    4. 2.4. Blueprint Modeling
    5. 2.5. Toolpath Planning for Bioprinting
    6. 2.6. Limitations
    7. 2.7. Future Directions
    8. 2.8. Summary
  11. 3. The Bioink
    1. 3.1. Introduction
    2. 3.2. Bioink Materials
    3. 3.3. Comparative Evaluation of Bioink Materials
    4. 3.4. Limitations
    5. 3.5. Future Directions
    6. 3.6. Summary
  12. 4. Extrusion-Based Bioprinting
    1. 4.1. Introduction
    2. 4.2. Extrusion-Based Bioprinting
    3. 4.3. Process Configurations
    4. 4.4. Comparison of Extrusion-Based Bioprinting With Other Bioprinting Techniques
    5. 4.5. Limitations
    6. 4.6. Future Directions
    7. 4.7. Summary
  13. 5. Droplet-Based Bioprinting
    1. 5.1. Introduction
    2. 5.2. Inkjet Bioprinting
    3. 5.3. Electrohydrodynamic Jet Bioprinting
    4. 5.4. Acoustic Bioprinting
    5. 5.5. Microvalve Bioprinting
    6. 5.6. Droplet-Substrate Interactions
    7. 5.7. Biomaterials Used in Droplet-Based Bioprinting
    8. 5.8. Comparison of Droplet-Based Bioprinting With Other Bioprinting Techniques
    9. 5.9. Recent Achievements in Droplet-Based Bioprinting
    10. 5.10. Limitations
    11. 5.11. Future Directions
    12. 5.12. Summary
  14. 6. Laser-Based Bioprinting
    1. 6.1. Introduction
    2. 6.2. Modalities of Laser-Based Bioprinting
    3. 6.3. Toward Multimaterial Bioprinting
    4. 6.4. Comparison of Laser-Based Bioprinting With Other Bioprinting Modalities
    5. 6.5. Recent Achievements in Laser-Based Bioprinting
    6. 6.6. Limitations
    7. 6.7. Future Directions
    8. 6.8. Summary
  15. 7. Bioprinter Technologies
    1. 7.1. Introduction
    2. 7.2. Bioprinters
    3. 7.3. Limitations
    4. 7.4. Future Directions
    5. 7.5. Summary
  16. 8. Roadmap to Organ Printing
    1. 8.1. Introduction
    2. 8.2. State-of-the-Art in Organ Printing
    3. 8.3. Roadmap to Organ Printing
    4. 8.4. Limitations
    5. 8.5. Future Directions
    6. 8.6. Summary
  17. 9. Applications of 3D Bioprinting
    1. 9.1. Introduction
    2. 9.2. Tissue Engineering and Regenerative Medicine
    3. 9.3. Transplantation and Clinics
    4. 9.4. Drug Screening and High-Throughput Assays
    5. 9.5. Cancer Research
    6. 9.6. Limitations
    7. 9.7. Future Directions
    8. 9.8. Summary
  18. 10. Future Trends
    1. 10.1. Introduction
    2. 10.2. Innovative Developments in Bioprinting Technology and Its Components
    3. 10.3. Toward Four-Dimensional Bioprinting
    4. 10.4. Toward Functional Organ Fabrication
    5. 10.5. From In Vitro to In Situ: Translation of Bioprinting Technologies Into Operating Rooms
    6. 10.6. Bioprinting New Types of Organs
    7. 10.7. Bioprinting Deoxyribonucleic Acid for Controlled Gene Therapy
    8. 10.8. Regulatory Issues
    9. 10.9. Summary
  19. Index