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23rd European Symposium on Computer Aided Process Engineering by Ilkka Turunen, Andrzej Kraslawski

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Hybrid advanced control of flexible multipurpose continuous tablet manufacturing process via direct compaction

Ravendra Singh, Marianthi Ierapetritou and Rohit Ramachandran,    ERC (SOPS), Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA

Abstract

The direct compaction continuous pharmaceutical tablet manufacturing process considered in this study is highly interactive and has time delays for several process variables due to sensor placements, that indicate that a simple feedback regulatory control system (e.g. PI(D)) by itself may not be sufficient to achieve the tight process control as imposed by regulatory authorities. This process comprises of coupled dynamics involving ...

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