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23rd European Symposium on Computer Aided Process Engineering by Ilkka Turunen, Andrzej Kraslawski

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Mixed integer optimisation of antibody purification processes

Songong Liua, Ana S. Simariab, Suzanne S. Faridb and Lazaros G. Papageorgioua,    aCentre for Process Systems Engineering, Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK, bThe Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK

Abstract

Chromatographic operations are identified as critical steps in a monoclonal antibody (mAb) purification process and can represent a significant proportion of the purification material costs. The optimisation of chromatography equipment sizing strategies is therefore crucial to improve the cost-effectiveness ...

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